Olaparib for advanced breast cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Olaparib, an oral PARP-inhibitor, has shown clinical benefit for HER2-negative advanced breast cancer patients carrying a germinal BRCA1/2 mutation. In a randomized Phase III trial, olaparib significantly prolonged progression-free survival as compared with chemotherapy of physician choice. Moreover, in the same trial, a prespecified subgroup analysis reported an overall survival benefit for patients not previously pretreated with chemotherapy for metastatic disease. This review focuses on available preclinical, pharmacokinetic and pharmacodynamic data regarding olaparib and clinical evidence of its antitumor efficacy (both as monotherapy and in combination) and tolerability in breast cancer patients. Open questions, such as use of appropriate biomarkers for patient selection and combination/sequencing with other anticancer drugs, are also addressed.

Original languageEnglish
Pages (from-to)717-732
Number of pages16
JournalFuture Oncology
Volume16
Issue number12
DOIs
Publication statusPublished - Apr 2020

Keywords

  • BRCA1
  • BRCA2
  • breast cancer
  • olaparib
  • OlympiAD
  • PARP
  • PARP inhibitor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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