Old and new prognostic factors in acute myeloid leukemia with deranged core-binding factor beta

Roberto Cairoli, Alessandro Beghini, Mauro Turrini, Giambattista Bertani, Gianpaolo Nadali, Francesco Rodeghiero, Carlo Castagnola, Francesca Lazzaroni, Michele Nichelatti, Felicetto Ferrara, Giovanni Pizzolo, Enrico Pogliani, Giuseppe Rossi, Giovanni Martinelli, Enrica Morra

Research output: Contribution to journalArticlepeer-review

Abstract

Acute myeloid leukemia (AML) with deranged core-binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50-70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ-AML aged ≤60 years. Increasing age was the only predictor for survival (P 9/L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069).

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalAmerican Journal of Hematology
Volume88
Issue number7
DOIs
Publication statusPublished - Jul 2013

ASJC Scopus subject areas

  • Hematology

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