Abstract
Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation of ambulation but with different side effects. Steroids clinical efficacy is now established. The main concern is to increase steroid efficacy and decrease side effect and toxicity. A trial comparing daily prednisone, deflazacort and intermittent glucocorticoids (prednisone 10 days on/10 days off) (FOR-DMD) is starting under NIH grant. The primary outcomes will be muscle strength, forced vital capacity and patient/parents satisfaction.
| Original language | English |
|---|---|
| Pages (from-to) | 9-15 |
| Number of pages | 7 |
| Journal | Acta Myologica |
| Volume | 31 |
| Issue number | MAY |
| Publication status | Published - May 2012 |
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Keywords
- DMD
- Duchenne
- Quality of life
- Side effect
- Steroids
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Old and new therapeutic developments in steroid treatment in Duchenne muscular dystrophy. / Angelini, Corrado; Peterle, Enrico.
In: Acta Myologica, Vol. 31, No. MAY, 05.2012, p. 9-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Old and new therapeutic developments in steroid treatment in Duchenne muscular dystrophy
AU - Angelini, Corrado
AU - Peterle, Enrico
PY - 2012/5
Y1 - 2012/5
N2 - Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation of ambulation but with different side effects. Steroids clinical efficacy is now established. The main concern is to increase steroid efficacy and decrease side effect and toxicity. A trial comparing daily prednisone, deflazacort and intermittent glucocorticoids (prednisone 10 days on/10 days off) (FOR-DMD) is starting under NIH grant. The primary outcomes will be muscle strength, forced vital capacity and patient/parents satisfaction.
AB - Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation of ambulation but with different side effects. Steroids clinical efficacy is now established. The main concern is to increase steroid efficacy and decrease side effect and toxicity. A trial comparing daily prednisone, deflazacort and intermittent glucocorticoids (prednisone 10 days on/10 days off) (FOR-DMD) is starting under NIH grant. The primary outcomes will be muscle strength, forced vital capacity and patient/parents satisfaction.
KW - DMD
KW - Duchenne
KW - Quality of life
KW - Side effect
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=84861681911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861681911&partnerID=8YFLogxK
M3 - Article
C2 - 22655511
AN - SCOPUS:84861681911
VL - 31
SP - 9
EP - 15
JO - Acta Myologica
JF - Acta Myologica
SN - 1128-2460
IS - MAY
ER -