Old and new therapeutic developments in steroid treatment in Duchenne muscular dystrophy

Corrado Angelini, Enrico Peterle

Research output: Contribution to journalArticlepeer-review

Abstract

Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation of ambulation but with different side effects. Steroids clinical efficacy is now established. The main concern is to increase steroid efficacy and decrease side effect and toxicity. A trial comparing daily prednisone, deflazacort and intermittent glucocorticoids (prednisone 10 days on/10 days off) (FOR-DMD) is starting under NIH grant. The primary outcomes will be muscle strength, forced vital capacity and patient/parents satisfaction.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalActa Myologica
Volume31
Issue numberMAY
Publication statusPublished - May 2012

Keywords

  • DMD
  • Duchenne
  • Quality of life
  • Side effect
  • Steroids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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