Abstract
To verify whether the sleep-inducing properties of oleamide were related to its ability to perturb membrane homeoviscosity, affecting 5-HT(2A) receptors, we compared the effects of oleamide and oleic acid, the latter lacking both the sleep-inducing effect and the action on 5-HT(2A) receptors. In binding studies the two compounds did not directly interact with rat brain cortex 5-HT(2A) receptors, nor did they increase the affinity of a 5-HT(2A) agonist, either in vitro or ex vivo. They had similar fluidizing effects, in vitro at high concentrations (≥10 μM), and ex vivo after a dose of 100 mg/kg, and they reduced locomotor activity with similar potency. There thus appears to be no causal relationship between the fluidizing effects of oleamide and its sleep-inducing properties.
Original language | English |
---|---|
Pages (from-to) | 281-284 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 463 |
Issue number | 3 |
DOIs | |
Publication status | Published - Dec 17 1999 |
Keywords
- 5-HT(2A) receptor
- Membrane homeoviscosity
- Oleamide
- Oleic acid
- Rat
- Sleep
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology