Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy

B. Galletti, R. Santoro, V. K. Mannella, F. Caminiti, L. Bonanno, S. De Salvo, G. Cammaroto, F. Galletti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective:: Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system. Methods:: Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials). Results:: Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls. Conclusion:: Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Laryngology and Otology
DOIs
Publication statusAccepted/In press - Mar 2 2016

Keywords

  • Chemotherapy
  • Nasopharyngeal Carcinoma
  • Olfactory Perception
  • Somatosensory Evoked Potentials; Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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