TY - JOUR
T1 - Olfactory event-related potentials
T2 - a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy
AU - Galletti, B.
AU - Santoro, R.
AU - Mannella, V. K.
AU - Caminiti, F.
AU - Bonanno, L.
AU - De Salvo, S.
AU - Cammaroto, G.
AU - Galletti, F.
PY - 2016/3/2
Y1 - 2016/3/2
N2 - Objective:: Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system. Methods:: Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials). Results:: Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls. Conclusion:: Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.
AB - Objective:: Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system. Methods:: Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials). Results:: Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls. Conclusion:: Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.
KW - Chemotherapy
KW - Nasopharyngeal Carcinoma
KW - Olfactory Perception
KW - Somatosensory Evoked Potentials; Radiotherapy
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U2 - 10.1017/S0022215116000761
DO - 10.1017/S0022215116000761
M3 - Article
C2 - 26931794
AN - SCOPUS:84959491475
SP - 1
EP - 9
JO - Journal of Laryngology and Otology
JF - Journal of Laryngology and Otology
SN - 0022-2151
ER -