TY - JOUR
T1 - Olfactory priming reinstates extinguished chocolate-induced conditioned place preference
AU - La Mela, Immacolata
AU - Latagliata, Emanuele Claudio
AU - Patrono, Enrico
AU - Puglisi-Allegra, Stefano
AU - Ventura, Rossella
PY - 2010/2
Y1 - 2010/2
N2 - A major problem in the dietary treatment of disorders associated with excessive eating, such as obesity, is the high rate of relapse into maladaptive eating habits after withdrawal from consumption of palatable, energy-dense food. As olfaction has a major role in appetite and eating behavior, in this study we used a reinstatement model based on conditioned place preference to investigate the ability of olfactory priming to reinstate extinguished chocolate-induced conditioned place preference in sated mice. We found that olfactory priming, which was ineffective in inducing conditioned place preference in the control group, reactivated place preference following the extinction procedure in the experimental group. These results extend previous reports of the reinstatement of food seeking induced by pellet priming and, for the first time, show the possibility of using olfactory priming in an animal model of relapse. In light of the major role of olfactory inputs in appetite and of cues in relapse, the present results indicate that smell is an important factor to consider in the treatment of eating disorders.
AB - A major problem in the dietary treatment of disorders associated with excessive eating, such as obesity, is the high rate of relapse into maladaptive eating habits after withdrawal from consumption of palatable, energy-dense food. As olfaction has a major role in appetite and eating behavior, in this study we used a reinstatement model based on conditioned place preference to investigate the ability of olfactory priming to reinstate extinguished chocolate-induced conditioned place preference in sated mice. We found that olfactory priming, which was ineffective in inducing conditioned place preference in the control group, reactivated place preference following the extinction procedure in the experimental group. These results extend previous reports of the reinstatement of food seeking induced by pellet priming and, for the first time, show the possibility of using olfactory priming in an animal model of relapse. In light of the major role of olfactory inputs in appetite and of cues in relapse, the present results indicate that smell is an important factor to consider in the treatment of eating disorders.
KW - Chocolate
KW - Mice
KW - Olfactory priming
KW - Reinstatement
UR - http://www.scopus.com/inward/record.url?scp=74449083809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74449083809&partnerID=8YFLogxK
U2 - 10.1016/j.appet.2009.12.008
DO - 10.1016/j.appet.2009.12.008
M3 - Article
C2 - 20006661
AN - SCOPUS:74449083809
VL - 54
SP - 237
EP - 240
JO - Appetite
JF - Appetite
SN - 0195-6663
IS - 1
ER -