Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis: Differences in repeated cerebrospinal fluid examinations

Roberto Bergamaschi, S. Tonietti, D. Franciotta, E. Candeloro, E. Tavazzi, G. Piccolo, A. Romani, V. Cosi

Research output: Contribution to journalArticle

Abstract

We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.

Original languageEnglish
Pages (from-to)2-4
Number of pages3
JournalMultiple Sclerosis Journal
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Oligoclonal Bands
Neuromyelitis Optica
Multiple Sclerosis
Cerebrospinal Fluid

Keywords

  • Cerebrospinal fluid
  • Devic's syndrome
  • Multiple sclerosis
  • Neuromyelitis optica
  • Oligoclonal bands

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis : Differences in repeated cerebrospinal fluid examinations. / Bergamaschi, Roberto; Tonietti, S.; Franciotta, D.; Candeloro, E.; Tavazzi, E.; Piccolo, G.; Romani, A.; Cosi, V.

In: Multiple Sclerosis Journal, Vol. 10, No. 1, 02.2004, p. 2-4.

Research output: Contribution to journalArticle

@article{1466c499155d439fb58a1ff34da720a3,
title = "Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis: Differences in repeated cerebrospinal fluid examinations",
abstract = "We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97{\%}) and never disappeared. In NMO, OBs were detected in three of 11 patients (27{\%}) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.",
keywords = "Cerebrospinal fluid, Devic's syndrome, Multiple sclerosis, Neuromyelitis optica, Oligoclonal bands",
author = "Roberto Bergamaschi and S. Tonietti and D. Franciotta and E. Candeloro and E. Tavazzi and G. Piccolo and A. Romani and V. Cosi",
year = "2004",
month = "2",
doi = "10.1191/1352458504ms988oa",
language = "English",
volume = "10",
pages = "2--4",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Oligoclonal bands in Devic's neuromyelitis optica and multiple sclerosis

T2 - Differences in repeated cerebrospinal fluid examinations

AU - Bergamaschi, Roberto

AU - Tonietti, S.

AU - Franciotta, D.

AU - Candeloro, E.

AU - Tavazzi, E.

AU - Piccolo, G.

AU - Romani, A.

AU - Cosi, V.

PY - 2004/2

Y1 - 2004/2

N2 - We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.

AB - We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations of oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected in 399 of 411 patients (97%) and never disappeared. In NMO, OBs were detected in three of 11 patients (27%) and always disappeared. The hypothesis that NMO and MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for the differentiation of NMO from MS.

KW - Cerebrospinal fluid

KW - Devic's syndrome

KW - Multiple sclerosis

KW - Neuromyelitis optica

KW - Oligoclonal bands

UR - http://www.scopus.com/inward/record.url?scp=0346707274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346707274&partnerID=8YFLogxK

U2 - 10.1191/1352458504ms988oa

DO - 10.1191/1352458504ms988oa

M3 - Article

C2 - 14760945

AN - SCOPUS:0346707274

VL - 10

SP - 2

EP - 4

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 1

ER -