Oligoclonality of CD8+ T cells in health and disease: Aging, infection, or immune regulation?

Franak Batliwalla, Joanita Monteiro, Davide Serrano, Peter K. Gregersen

Research output: Contribution to journalArticle

Abstract

Oligoclonality of the CD8+ T cell subset is a common and characteristic feature of the normal human peripheral T cell repertoire. These clonally expanded populations are predominantly found in a CD57+ or CD28- CD8+ T cell subset. While CD8 oligoclonality is somewhat more common in the older age group, it is also very prevalent in young to middle-aged adults. Recent experiments have also demonstrated that the clonally expanded populations may actually occur in two distinct subpopulations of CD8+ CD28- cells, distinguished by the expression of the CD57 surface marker. A major difficulty with studies involving CD8+ CD28- CD57+ T cells is their relative lack of proliferative capacity. We have recently investigated the possibility that this phenotype may be due to a state of 'replicative senescence' in some cases. In this regard, we have demonstrated that the telomere lengths of CD8+ CD28- T cells are generally shorter than that of their CD8+ CD28+ counterparts, consistent with a distinct replicative history for the CD8+ CD28- population. Additional studies of the normal biology of clonally expanded CD8+ T cells are likely to yield important insights into immune function in health and disease.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalHuman Immunology
Volume48
Issue number1-2
DOIs
Publication statusPublished - Jun 1996

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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