Oligodendroglial hamartoma: A potential source of misdiagnosis for oligodendroglioma

Gianluca Marucci, Marco Giulioni, Matteo Martinoni, Lilia Volpi, Roberto Michelucci

Research output: Contribution to journalArticlepeer-review


Various subtypes of intracerebral hamartomas, associated with seizure disorders, have long been described. We describe a cerebral hamartoma placed in the left frontal lobe, associated with drug-resistant epilepsy, composed exclusively of mature oligodendroglial cells. The patient was a 27-year-old right-handed male presenting with severe epileptic encephalopathy and symptoms of behavior dysfunction (disinhibition, rage attacks) associated with a left frontal lesion. Magnetic resonance imaging revealed a small area iso-hypointense compared to the gray matter in T1-weighted sequences not enhancing after gadolinium contrast injection in the left frontal site. On histology, a cortical lesion composed of large aggregates of oligodendroglial cells, with round central nuclei and clear perinuclear halos, was observed. Neither mitotic figures nor necrosis were present. Reactivity for Ki67 and P53 was not found. The lesion was well demarcated from the adjacent brain parenchyma and perineuronal satellitosis was not observed in the cortex. In conclusion, albeit extremely rare, recognition of oligodendroglial hamartoma and its distinction from other epileptogenic lesions as dysembryoplastic neuroepithelial tumor or above all oligodendroglioma have important therapeutic and prognostic implications.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalJournal of Neuro-Oncology
Issue number2
Publication statusPublished - Jan 2011


  • Dysembryoplastic neuroepithelial tumor
  • Epilepsy
  • Epilepsy surgery
  • Oligodendroglial hamartoma
  • Oligodendroglioma

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology


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