Oligonucleotide delivery by cell-penetrating "striped" nanoparticles

Christopher M. Jewell, Jin Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci, Darrell J. Irvine

Research output: Contribution to journalArticlepeer-review

Abstract

Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished.

Original languageEnglish
Pages (from-to)12312-12315
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number51
DOIs
Publication statusPublished - Dec 16 2011

Keywords

  • DNA delivery
  • endocytosis
  • gene therapy
  • gold nanoparticles
  • ligands (organic)

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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