Olive oil and cancer risk: An update of epidemiological findings through 2010

Claudio Pelucchi, Cristina Bosetti, Eva Negri, Loren Lipworth, Carlo la Vecchia

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Consumption of olive oil has been related to reduced risk of several diseases, including various neoplasms. In this paper, we reviewed epidemiological studies on olive oil and cancer published up to 2010. We performed a systematic literature search in the Medline database and, after assessment of relevant papers, we included 25 studies providing original data on olive oil consumption and cancer risk. We also performed a meta-analysis of studies of breast cancer, calculating the pooled relative risk (RR), and the corresponding 95% confidence intervals (CI), for high vs. low olive oil consumption. Several studies conducted in Southern Europe reported olive oil consumption as a favourable indicator of breast, digestive tract, and particularly upper aero-digestive tract cancers. For the latter, after adjustment for alcohol and tobacco use, the RRs between extreme levels of olive oil consumption were 0.3-0.4, and there was an over 5-fold difference in risk between subjects consuming mainly olive oil and those consuming mainly butter. The summary RR of breast cancer was 0.62 (95% CI, 0.44-0.88) for the highest vs. lowest level of olive oil consumption. Thus, preferring olive oil to other added lipids, particularly those rich in saturated fats, can decrease the risk of upper digestive and respiratory tract neoplasms, breast and, possibly, colorectal and other cancer sites.

Original languageEnglish
Pages (from-to)805-812
Number of pages8
JournalCurrent Pharmaceutical Design
Volume17
Issue number8
DOIs
Publication statusPublished - 2011

Fingerprint

Neoplasms
Gastrointestinal Tract
Respiratory Tract Neoplasms
Breast
Confidence Intervals
Breast Neoplasms
Olive Oil
Butter
Tobacco Use
Meta-Analysis
Epidemiologic Studies
Colorectal Neoplasms
Fats
Alcohols
Databases
Lipids

Keywords

  • Dietary fats
  • Epidemiology
  • Neoplasms
  • Olive oil
  • Review
  • Risk factors

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Olive oil and cancer risk : An update of epidemiological findings through 2010. / Pelucchi, Claudio; Bosetti, Cristina; Negri, Eva; Lipworth, Loren; la Vecchia, Carlo.

In: Current Pharmaceutical Design, Vol. 17, No. 8, 2011, p. 805-812.

Research output: Contribution to journalArticle

Pelucchi, Claudio ; Bosetti, Cristina ; Negri, Eva ; Lipworth, Loren ; la Vecchia, Carlo. / Olive oil and cancer risk : An update of epidemiological findings through 2010. In: Current Pharmaceutical Design. 2011 ; Vol. 17, No. 8. pp. 805-812.
@article{323e645c7caa44679b8b3c448999827c,
title = "Olive oil and cancer risk: An update of epidemiological findings through 2010",
abstract = "Consumption of olive oil has been related to reduced risk of several diseases, including various neoplasms. In this paper, we reviewed epidemiological studies on olive oil and cancer published up to 2010. We performed a systematic literature search in the Medline database and, after assessment of relevant papers, we included 25 studies providing original data on olive oil consumption and cancer risk. We also performed a meta-analysis of studies of breast cancer, calculating the pooled relative risk (RR), and the corresponding 95{\%} confidence intervals (CI), for high vs. low olive oil consumption. Several studies conducted in Southern Europe reported olive oil consumption as a favourable indicator of breast, digestive tract, and particularly upper aero-digestive tract cancers. For the latter, after adjustment for alcohol and tobacco use, the RRs between extreme levels of olive oil consumption were 0.3-0.4, and there was an over 5-fold difference in risk between subjects consuming mainly olive oil and those consuming mainly butter. The summary RR of breast cancer was 0.62 (95{\%} CI, 0.44-0.88) for the highest vs. lowest level of olive oil consumption. Thus, preferring olive oil to other added lipids, particularly those rich in saturated fats, can decrease the risk of upper digestive and respiratory tract neoplasms, breast and, possibly, colorectal and other cancer sites.",
keywords = "Dietary fats, Epidemiology, Neoplasms, Olive oil, Review, Risk factors",
author = "Claudio Pelucchi and Cristina Bosetti and Eva Negri and Loren Lipworth and {la Vecchia}, Carlo",
year = "2011",
doi = "10.2174/138161211795428920",
language = "English",
volume = "17",
pages = "805--812",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Olive oil and cancer risk

T2 - An update of epidemiological findings through 2010

AU - Pelucchi, Claudio

AU - Bosetti, Cristina

AU - Negri, Eva

AU - Lipworth, Loren

AU - la Vecchia, Carlo

PY - 2011

Y1 - 2011

N2 - Consumption of olive oil has been related to reduced risk of several diseases, including various neoplasms. In this paper, we reviewed epidemiological studies on olive oil and cancer published up to 2010. We performed a systematic literature search in the Medline database and, after assessment of relevant papers, we included 25 studies providing original data on olive oil consumption and cancer risk. We also performed a meta-analysis of studies of breast cancer, calculating the pooled relative risk (RR), and the corresponding 95% confidence intervals (CI), for high vs. low olive oil consumption. Several studies conducted in Southern Europe reported olive oil consumption as a favourable indicator of breast, digestive tract, and particularly upper aero-digestive tract cancers. For the latter, after adjustment for alcohol and tobacco use, the RRs between extreme levels of olive oil consumption were 0.3-0.4, and there was an over 5-fold difference in risk between subjects consuming mainly olive oil and those consuming mainly butter. The summary RR of breast cancer was 0.62 (95% CI, 0.44-0.88) for the highest vs. lowest level of olive oil consumption. Thus, preferring olive oil to other added lipids, particularly those rich in saturated fats, can decrease the risk of upper digestive and respiratory tract neoplasms, breast and, possibly, colorectal and other cancer sites.

AB - Consumption of olive oil has been related to reduced risk of several diseases, including various neoplasms. In this paper, we reviewed epidemiological studies on olive oil and cancer published up to 2010. We performed a systematic literature search in the Medline database and, after assessment of relevant papers, we included 25 studies providing original data on olive oil consumption and cancer risk. We also performed a meta-analysis of studies of breast cancer, calculating the pooled relative risk (RR), and the corresponding 95% confidence intervals (CI), for high vs. low olive oil consumption. Several studies conducted in Southern Europe reported olive oil consumption as a favourable indicator of breast, digestive tract, and particularly upper aero-digestive tract cancers. For the latter, after adjustment for alcohol and tobacco use, the RRs between extreme levels of olive oil consumption were 0.3-0.4, and there was an over 5-fold difference in risk between subjects consuming mainly olive oil and those consuming mainly butter. The summary RR of breast cancer was 0.62 (95% CI, 0.44-0.88) for the highest vs. lowest level of olive oil consumption. Thus, preferring olive oil to other added lipids, particularly those rich in saturated fats, can decrease the risk of upper digestive and respiratory tract neoplasms, breast and, possibly, colorectal and other cancer sites.

KW - Dietary fats

KW - Epidemiology

KW - Neoplasms

KW - Olive oil

KW - Review

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=79958187582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958187582&partnerID=8YFLogxK

U2 - 10.2174/138161211795428920

DO - 10.2174/138161211795428920

M3 - Article

C2 - 21443483

AN - SCOPUS:79958187582

VL - 17

SP - 805

EP - 812

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 8

ER -