Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kB SIgnaling

Mario Dell'Agli, Rossana Fagnani, Germana V. Galli, Omar Maschi, Federica Gilardi, Stefano Bellosta, Maurizio Crestani, Enrica Bosisio, Emma De Fabiani, Donatella Caruso

Research output: Contribution to journalArticle

Abstract

In vivo studies suggest that the phenolic component contributes to the anti-inflammatory and antiatherosclerotic actions of olive oil; however, the effects In circulating cells are not fully characterized. Monocytes play a key role in inflammation-based diseases by expressing several molecules, Including metalloproteinases (MMPs). In the present study, we investigated the effects of olive oil phenolic extract and Individual compounds on MMP-9 in THP-1 cells, a human monocyte-like cell line. Olive oil extract prevented the stimulation of MMP-9 expression and secretion in tumor necrosis factor α-treated THP-1 cells. Oleuropein aglycone, a typical olive oil phenol, was active at concentrations found in the extract, although other compounds probably contribute to the biological activity. We also found that the effect of the extract and individual compounds on MMP-9 is due to impaired nuclear factor-kB signaling. Our findings provide further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis.

Original languageEnglish
Pages (from-to)2246-2252
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number4
DOIs
Publication statusPublished - Feb 24 2010

Keywords

  • Inflammation
  • Metalloprotease-9
  • Monocytes
  • Nf-kb
  • Olive oil phenols
  • Oluropein aglycone

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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    Dell'Agli, M., Fagnani, R., Galli, G. V., Maschi, O., Gilardi, F., Bellosta, S., Crestani, M., Bosisio, E., De Fabiani, E., & Caruso, D. (2010). Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kB SIgnaling. Journal of Agricultural and Food Chemistry, 58(4), 2246-2252. https://doi.org/10.1021/jf9042503