Olive polyphenol effects in a mouse model of chronic ethanol addiction

Valentina Carito, Mauro Ceccanti, Vincenzo Cestari, Fausta Natella, Cristiano Bello, Roberto Coccurello, Rosanna Mancinelli, Marco Fiore

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress.

METHODS: We administered (per os) for two months 20 mg/kg of olive polyphenols containing mostly hydroxytyrosol in alcoholic adult male mice. Hydroxytyrosol metabolites as hydroxytyrosol sulfate 1 and hydroxytyrosol sulfate 2 were found in the serum of mice administered with polyphenols with the highest amount in animals treated with both polyphenols and alcohol. Oxidative stress was evaluated by FORT (free oxygen radical test) and FORD (free oxygen radical defense) tests.

RESULTS: Alcoholic mice showed a worse oxidative status than nonalcoholic mice (higher FORT and lower FORD) but polyphenol supplementation partially counteracted the alcohol pro-oxidant effects, as evidenced by FORT.

CONCLUSIONS: A better understanding of the antioxidant protection provided by polyphenols might be of primary interest for drug discovery and dietary-based prevention of the damage associated with chronic alcohol abuse.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalNutrition
Volume33
DOIs
Publication statusE-pub ahead of print - Sep 20 2016

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Polyphenols
Olea
Ethanol
Reactive Oxygen Species
Free Radicals
Alcohols
Alcoholism
Sulfates
Oxidative Stress
Antioxidants
Drug Discovery
3,4-dihydroxyphenylethanol
Serum

Keywords

  • Journal Article

Cite this

Carito, V., Ceccanti, M., Cestari, V., Natella, F., Bello, C., Coccurello, R., ... Fiore, M. (2016). Olive polyphenol effects in a mouse model of chronic ethanol addiction. Nutrition, 33, 65-69. https://doi.org/10.1016/j.nut.2016.08.014

Olive polyphenol effects in a mouse model of chronic ethanol addiction. / Carito, Valentina; Ceccanti, Mauro; Cestari, Vincenzo; Natella, Fausta; Bello, Cristiano; Coccurello, Roberto; Mancinelli, Rosanna; Fiore, Marco.

In: Nutrition, Vol. 33, 20.09.2016, p. 65-69.

Research output: Contribution to journalArticle

Carito, V, Ceccanti, M, Cestari, V, Natella, F, Bello, C, Coccurello, R, Mancinelli, R & Fiore, M 2016, 'Olive polyphenol effects in a mouse model of chronic ethanol addiction', Nutrition, vol. 33, pp. 65-69. https://doi.org/10.1016/j.nut.2016.08.014
Carito, Valentina ; Ceccanti, Mauro ; Cestari, Vincenzo ; Natella, Fausta ; Bello, Cristiano ; Coccurello, Roberto ; Mancinelli, Rosanna ; Fiore, Marco. / Olive polyphenol effects in a mouse model of chronic ethanol addiction. In: Nutrition. 2016 ; Vol. 33. pp. 65-69.
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AU - Carito, Valentina

AU - Ceccanti, Mauro

AU - Cestari, Vincenzo

AU - Natella, Fausta

AU - Bello, Cristiano

AU - Coccurello, Roberto

AU - Mancinelli, Rosanna

AU - Fiore, Marco

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

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N2 - OBJECTIVES: Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress.METHODS: We administered (per os) for two months 20 mg/kg of olive polyphenols containing mostly hydroxytyrosol in alcoholic adult male mice. Hydroxytyrosol metabolites as hydroxytyrosol sulfate 1 and hydroxytyrosol sulfate 2 were found in the serum of mice administered with polyphenols with the highest amount in animals treated with both polyphenols and alcohol. Oxidative stress was evaluated by FORT (free oxygen radical test) and FORD (free oxygen radical defense) tests.RESULTS: Alcoholic mice showed a worse oxidative status than nonalcoholic mice (higher FORT and lower FORD) but polyphenol supplementation partially counteracted the alcohol pro-oxidant effects, as evidenced by FORT.CONCLUSIONS: A better understanding of the antioxidant protection provided by polyphenols might be of primary interest for drug discovery and dietary-based prevention of the damage associated with chronic alcohol abuse.

AB - OBJECTIVES: Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress.METHODS: We administered (per os) for two months 20 mg/kg of olive polyphenols containing mostly hydroxytyrosol in alcoholic adult male mice. Hydroxytyrosol metabolites as hydroxytyrosol sulfate 1 and hydroxytyrosol sulfate 2 were found in the serum of mice administered with polyphenols with the highest amount in animals treated with both polyphenols and alcohol. Oxidative stress was evaluated by FORT (free oxygen radical test) and FORD (free oxygen radical defense) tests.RESULTS: Alcoholic mice showed a worse oxidative status than nonalcoholic mice (higher FORT and lower FORD) but polyphenol supplementation partially counteracted the alcohol pro-oxidant effects, as evidenced by FORT.CONCLUSIONS: A better understanding of the antioxidant protection provided by polyphenols might be of primary interest for drug discovery and dietary-based prevention of the damage associated with chronic alcohol abuse.

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