Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy

Mario Savoiardo, Liliana Strada, Floriano Girotti, Robert A. Zimmerman, Marina Grisoli, Daniela Testa, Raffaele Petrillo

Research output: Contribution to journalArticle

Abstract

Clinical diagnosis of olivopontocerebellar atrophy (OPCA) must be confirmed by radiologic demonstration of atrophy in an appropriate distribution. OPCA may be associated with degeneration of other systems in multisystem atrophy (MSA). The authors report 23 cases of OPCA, eight of which were associated with MSA. Atrophy involved the cerebellum, pons, and middle cerebellar peduncles in all cases. On intermediate and T2-weighted magnetic resonance (MR) images, abnormal signal intensity was always observed in the transverse pontine fibers, middle cerebellar peduncles, and cerebellum, structures known from pathologic study to degenerate in OPCA. Pyramidal tracts and superior cerebellar peduncles stood out because of their normal signal intensity. Of the eight patients with MSA, four also had variable abnormal signal intensities in the putamen. The authors believe that the combination of atrophy and abnormal signal intensity in the appropriate distribution strongly supports the diagnosis of OPCA. In some cases, MR imaging may demonstrate involvement of different systems, thus confirming the diagnosis of MSA.

Original languageEnglish
Pages (from-to)693-696
Number of pages4
JournalRadiology
Volume174
Issue number3
Publication statusPublished - Mar 1990

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Olivopontocerebellar Atrophies
Multiple System Atrophy
Magnetic Resonance Spectroscopy
Atrophy
Cerebellum
Pyramidal Tracts
Pons
Putamen
Magnetic Resonance Imaging

Keywords

  • Atrophy, 15.83
  • Basal ganglia, MR studies 15.1214 Brain
  • Brain stem, MR studies, 15.1214
  • Brain, diseases, 15.83
  • Brain, MR studies, 10.1214

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Savoiardo, M., Strada, L., Girotti, F., Zimmerman, R. A., Grisoli, M., Testa, D., & Petrillo, R. (1990). Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology, 174(3), 693-696.

Olivopontocerebellar atrophy : MR diagnosis and relationship to multisystem atrophy. / Savoiardo, Mario; Strada, Liliana; Girotti, Floriano; Zimmerman, Robert A.; Grisoli, Marina; Testa, Daniela; Petrillo, Raffaele.

In: Radiology, Vol. 174, No. 3, 03.1990, p. 693-696.

Research output: Contribution to journalArticle

Savoiardo, M, Strada, L, Girotti, F, Zimmerman, RA, Grisoli, M, Testa, D & Petrillo, R 1990, 'Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy', Radiology, vol. 174, no. 3, pp. 693-696.
Savoiardo M, Strada L, Girotti F, Zimmerman RA, Grisoli M, Testa D et al. Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology. 1990 Mar;174(3):693-696.
Savoiardo, Mario ; Strada, Liliana ; Girotti, Floriano ; Zimmerman, Robert A. ; Grisoli, Marina ; Testa, Daniela ; Petrillo, Raffaele. / Olivopontocerebellar atrophy : MR diagnosis and relationship to multisystem atrophy. In: Radiology. 1990 ; Vol. 174, No. 3. pp. 693-696.
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