Omega 3 polyunsaturated fatty acids supplementation and blood pressure levels in hypertriglyceridemic patients with untreated normal-high blood pressure and with or without metabolic syndrome: A retrospective study

Arrigo F G Cicero, Giuseppe Derosa, Valentina Di Gregori, Marilisa Bove, Antonio V. Gaddi, Claudio Borghi

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence suggests that at least a part of the polyunsaturated fatty acids (PUFAs) heart protective effect is mediated by a relatively small but significant decrease in blood pressure level. We retrospectively evaluated the long-term effect of a PUFA supplementation on the blood pressure level of 111 hypertriglyceridemic subjects with untreated normal-high blood pressure that were prescribed a 2 grams PUFA supplementation in order to improve their plasma lipid pattern. After 12 months of treatment, systolic blood pressure (SBP) meanly decreased by 2.7 ± 2.5 mmHg (p =0.001) and diastolic blood pressure (DBP) by 1.3 ± 3.3 mmHg (p <0.001), while basal heart rate decreased by 4.0 ± 4.4 bpm (p <0.001). Both SBP and DBP reduction were significantly related to the baseline SBP (p <0.001) and DBP (p <0.001), respectively. Diastolic blood pressure change was also inversely related to the patient's age (p = 0.004). No significant difference was perceived in the metabolic syndrome subgroup. In our retrospective study, highly purified omega-3 PUFA long-term supplementation is associated with a significant reduction in SBP, DBP, Pulse pressure (PP), and basal heart rate in hypertriglyceridemic patients with normal-high blood pressure. No significant difference was perceived in the metabolic syndrome subgroup. The main determinants of the PUFA anti-hypertensive effect appear to be the basal blood pressure level and age.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalClinical and Experimental Hypertension
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Blood pressure
  • Fish oil
  • Hypertension
  • Omega 3 fatty acids
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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