Omic approaches to pediatric bone sarcomas

Elisa Tirtei, Matteo Cereda, Elvira De Luna, Paola Quarello, Sebastian Dorin Asaftei, Franca Fagioli

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the last decade, next-generation sequencing technologies have improved our ability to assess biological aspects, at genomic and transcriptomic levels, on a large scale- and have been increasingly used for the management of adult cancers. However, their efficacy and feasibility within pediatrics is still under investigation. "Omic" approaches represent an opportunity to understand the oncogenic mechanisms driving the onset and progression of bone sarcoma and improve the clinical management of young patients with bone sarcomas. This review focuses on the current genomic and transcriptomic characteristics of managing pediatric patients, affected by Ewing sarcoma and osteosarcoma.

Original languageEnglish
Pages (from-to)e28072
JournalPediatric Blood and Cancer
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Biomarkers, Tumor/genetics
  • Bone Neoplasms/genetics
  • Genomics/methods
  • Humans
  • Osteosarcoma/genetics
  • Sarcoma, Ewing/genetics
  • Transcriptome

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