“Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome”

Valeria Marzano, Livia Mancinelli, Giorgia Bracaglia, Federica Del Chierico, Pamela Vernocchi, Francesco Di Girolamo, Stefano Garrone, Hyppolite Tchidjou Kuekou, Patrizia D’Argenio, Bruno Dallapiccola, Andrea Urbani, Lorenza Putignani

Research output: Contribution to journalArticlepeer-review

Abstract

The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic “citizens.” In the past few decades, numerous studies have highlighted the composition and role of human intestinal bacteria in physiological and pathological conditions, while few investigations exist on gut parasites and particularly on their coexistence and interaction with the intestinal microbiota. Studies of the gut “parasitome” through “omic” technologies, such as (meta)genomics, transcriptomics, proteomics, and metabolomics, are herein reviewed to better understand their role in the relationships between intestinal parasites, host, and resident prokaryotes, whether pathogens or commensals. Systems biology–based profiles of the gut “parasitome” under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.
Original languageEnglish
JournalPLoS Neglected Tropical Diseases
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2 2017

Fingerprint

Dive into the research topics of '“Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome”'. Together they form a unique fingerprint.

Cite this