Omics underpins novel clues on VDR chemoprevention target in breast cancer

Paola Muti, Barbara Benassi, Elisabetta Falvo, Raffaela Santoro, Sergio Galanti, Gennaro Citro, Giuseppe Carrubba, Giovanni Blandino, Sabrina Strano

Research output: Contribution to journalArticle

Abstract

Breast cancer is the commonest form of female malignancy among women in Western countries. The advent of genomic technologies has enhanced the diagnosis and the biological classification of such pathology. It has been demonstrated that cancer takes many years to be fully established. This long dormancy could represent a potential window for intervening with chemoprevention studies. Cancer chemoprevention is by definition the use of natural, synthetic, or biological chemical agents to reverse, suppress, or delay the genetic or other alterations that culminate in the appearance of the tumor phenotype. An important step for the success of chemoprevention is the identification of molecularly targeted agents to prevent cancer development. Currently, only two chemoprevention agents, raloxifene and tamoxifen, are used in clinical practice to prevent breast cancer. In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer.

Original languageEnglish
Pages (from-to)337-346
Number of pages10
JournalOMICS A Journal of Integrative Biology
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this