Omission of lymphadenectomy in low risk prostate cancer

Angelo Naselli, Rossana Andreatta, Carlo Introini, Vincenzo Fontana, Paolo Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present study was to evaluate if lymphadenectomy could be safely spared in low risk prostate cancer (PC) patients. Patients and Methods: From 5/1998 to 10/2005, 100 patients with low risk prostate cancer who had undergone radical prostatectomy (RP) and did not have positive surgical margins were selected. The series included 34 patients submitted to lymphadenectomy including the iliac and obturatory nodes without documented nodal metastasis. Results: Fifteen patients experienced a biochemical relapse (BR) at a median follow-up of 1.7 years. The pathological stage and not removing the nodes were both significant predictors of biochemical relapse (p-value=0.008 and 0.018) in univariate analysis. Adjusting for baseline imbalances through the Cox's regression model, a relative risk of BR which was more than five-fold higher in patients who had not been subjected to lymphadenectomy (p-value

Original languageEnglish
Pages (from-to)4451-4456
Number of pages6
JournalAnticancer Research
Volume27
Issue number6 C
Publication statusPublished - Nov 2007

Keywords

  • Cox's regression
  • Prostate cancer
  • Radical prostatectomy
  • Risk assessment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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