On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals

Ren Iwata, Claudio Pascali, Mitsuaki Yuasa, Kazuhiko Yanai, Toshihiro Takahashi, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review


A novel method for the efficient preparation of 11C-radiopharmaceuticals by on-line [11C]methylation using [11C]methyl iodide has been developed and applied to a rapid, convenient automated system. [11C]Methyl iodide is first trapped in a short column, containing an adsorber and coated substrate, which is connected to an HPLC injector. DMF is then introduced. Alternatively the substrate is added with the DMF. A whole reaction mixture can be easily injected onto an HPLC column for purification by switching the injector valve immediately after the reaction. Thus, radiochemical yields in the preparation of 11C-labeled doxepin, benztropine, cyproheptadine and N-methylspiperone have been improved remarkably and the synthetic procedure simplified.

Original languageEnglish
Pages (from-to)1083-1088
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Issue number9
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Medicine(all)
  • Radiation


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