On the Alert for Cytokine Storm: Immunopathology in COVID-19

Lauren A Henderson, Scott W Canna, Grant S Schulert, Stefano Volpi, Pui Y Lee, Kate F Kernan, Roberto Caricchio, Shawn Mahmud, Melissa M Hazen, Olha Halyabar, Kacie J Hoyt, Joseph Han, Alexei A Grom, Marco Gattorno, Angelo Ravelli, Fabrizio De Benedetti, Edward M Behrens, Randy Q Cron, Peter A Nigrovic

Research output: Contribution to journalArticlepeer-review


Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.

Original languageEnglish
Pages (from-to)1059-1063
Number of pages5
JournalArthritis Rheum.
Issue number7
Publication statusPublished - Jul 2020


  • Anti-Inflammatory Agents/therapeutic use
  • Betacoronavirus
  • Biomarkers
  • COVID-19
  • Coronavirus Infections/complications
  • Cytokine Release Syndrome/diagnosis
  • Early Medical Intervention
  • Humans
  • Pandemics
  • Pneumonia, Viral/complications
  • SARS-CoV-2


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