On the immunocytochemical localization of the vasoactive intestinal polypeptide

L. I. Larsson, J. M. Polak, R. Buffa, F. Sundler, E. Solcia

Research output: Contribution to journalArticlepeer-review


The distribution of vasoactive intestinal polypeptide (VIP) immunoreactive nerves and endocrine cells in the gastrointestinal tract and pancreas of a number of mammalian and submammalian species has been examined in order to throw light on the exact localization of this peptide. Seven out of 8 VIP antisera demonstrated numerous nerve fibers in the gut, whereas one antiserum (TR2) revealed only scattered, few nerve fibers. The distribution of endocrine cells demonstrated by the different VIP antisera varied considerably. Thus, some antisera demonstrated only endocrine cells of the upper gut and pancreas. The variability in staining pattern of endocrine cells as well as recent radioimmunological data makes it opportune to suggest that true VIP is a neuronal peptide and that endocrine cells store peptides resembling, but not being identical with, VIP (VIPoids).

Original languageEnglish
Pages (from-to)936-938
Number of pages3
JournalJournal of Histochemistry and Cytochemistry
Issue number5
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology


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