On the measurement of the functional properties of the CFTR

Oscar Moran, Olga Zegarra-Moran

Research output: Contribution to journalArticlepeer-review


A number of methods are currently employed to assess the functional properties of CFTR channels and their response to pharmacological potentiators, correction of the defective CFTR trafficking, and vectorial introduction of new proteins. Here we review the most common methods used to assess CFTR channel function. The suitability of each technique to various experimental conditions is discussed.

Original languageEnglish
Pages (from-to)483-494
Number of pages12
JournalJournal of Cystic Fibrosis
Issue number6
Publication statusPublished - Nov 2008


  • CFTR
  • Chloride flux
  • Chloride transport
  • Ionic current
  • Membrane potential

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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