On the measurement of the functional properties of the CFTR

Oscar Moran; Olga Zegarra-Moran

doi:10.1016/j.jcf.2008.05.003

On the measurement of the functional properties of the CFTR

Oscar Moran, Olga Zegarra-Moran

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

A number of methods are currently employed to assess the functional properties of CFTR channels and their response to pharmacological potentiators, correction of the defective CFTR trafficking, and vectorial introduction of new proteins. Here we review the most common methods used to assess CFTR channel function. The suitability of each technique to various experimental conditions is discussed.

Original language	English
Pages (from-to)	483-494
Number of pages	12
Journal	Journal of Cystic Fibrosis
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.jcf.2008.05.003
Publication status	Published - Nov 2008

Keywords

CFTR
Chloride flux
Chloride transport
Ionic current
Membrane potential

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2008.05.003

Cite this

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abstract = "A number of methods are currently employed to assess the functional properties of CFTR channels and their response to pharmacological potentiators, correction of the defective CFTR trafficking, and vectorial introduction of new proteins. Here we review the most common methods used to assess CFTR channel function. The suitability of each technique to various experimental conditions is discussed.",

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KW - Ionic current

KW - Membrane potential

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On the measurement of the functional properties of the CFTR

Abstract

Keywords

ASJC Scopus subject areas

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