On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system

Alberto Mantovani, Federico Spreafico

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalEuropean Journal of Cancer (1965)
Volume11
Issue number6
DOIs
Publication statusPublished - 1975

Fingerprint

Antigen-Antibody Complex
Lymphocytes
Leukemia L1210
Inbred C3H Mouse
Antibodies
Serum
Neoplasms
Population
blocking factor

ASJC Scopus subject areas

  • Oncology

Cite this

On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system. / Mantovani, Alberto; Spreafico, Federico.

In: European Journal of Cancer (1965), Vol. 11, No. 6, 1975, p. 451-455.

Research output: Contribution to journalArticle

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