On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system

Alberto Mantovani; Federico Spreafico

doi:10.1016/0014-2964(75)90077-8

On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system

Alberto Mantovani, Federico Spreafico

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Employing the allogeneic tumor system of C3H mice transplanted with the L₁₂₁₀ leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.

Original language	English
Pages (from-to)	451-455
Number of pages	5
Journal	European Journal of Cancer (1965)
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/0014-2964(75)90077-8
Publication status	Published - 1975

ASJC Scopus subject areas

Oncology

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title = "On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system",

abstract = "Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.",

author = "Alberto Mantovani and Federico Spreafico",

year = "1975",

doi = "10.1016/0014-2964(75)90077-8",

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AU - Spreafico, Federico

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AB - Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.

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