Abstract
Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.
| Original language | English |
|---|---|
| Pages (from-to) | 451-455 |
| Number of pages | 5 |
| Journal | European Journal of Cancer (1965) |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1975 |
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ASJC Scopus subject areas
- Oncology
Cite this
On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system. / Mantovani, Alberto; Spreafico, Federico.
In: European Journal of Cancer (1965), Vol. 11, No. 6, 1975, p. 451-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On the nature of blocking factors and their lymphoid target cells in an allogeneic tumor system
AU - Mantovani, Alberto
AU - Spreafico, Federico
PY - 1975
Y1 - 1975
N2 - Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.
AB - Employing the allogeneic tumor system of C3H mice transplanted with the L1210 leukemia, evidence was obtained that serum blocking activity can be due to antigen-antibody complexes. In this system, the cytotoxic activity induced in normal splenocytes by arming antibody is not modified by exposure to blocking sera. It is suggested that in allogeneic tumor systems, blockade can be due to antigen-antibody complexes and that blocking factors and arming antibodies act on different lymphoid populations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016735869&partnerID=8YFLogxK
U2 - 10.1016/0014-2964(75)90077-8
DO - 10.1016/0014-2964(75)90077-8
M3 - Article
VL - 11
SP - 451
EP - 455
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 6
ER -