On the nature of the metachromatic cells of pancreatic islets

Enrico Solcia, Roberto Sampietro

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Islet cells with cytoplasmic granules metachromatically stained by toluidine blue are found in the pancreas of dog, cat, pig, rabbit, teleostian fish, monkey and man, but not in the rat, mouse and guinea pig; dubious results are obtained on duck and ox islets. These cells do not react with the staining methods for the demonstration of A- and B-cells; conversely, they are silver-impregnated by a modification of Davenport's method, and, at least in dog islets, can be readily identified with dark-field microscopy and stained blue with the Mallory-Heidenhain trichrome stain. No obvious changes of this cell type are found either in synthalintreated dogs or in diabetic men. The Authors suggest that the islet argyrophil-metachromatic cells (A1-cells of Swedish Authors) are identical with D-cells and very likely represent a morphologically and functionally indipendent cell type.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalZeitschrift für Zellforschung und Mikroskopische Anatomie
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 1964

Fingerprint

Tolonium Chloride
Islets of Langerhans
Silver
Fish
Rats
Microscopic examination
Demonstrations
Cells
Dogs
Cytoplasmic Granules
Somatostatin-Secreting Cells
Ducks
Haplorhini
Pancreas
Microscopy
Guinea Pigs
Fishes
Cats
B-Lymphocytes
Swine

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Anatomy

Cite this

On the nature of the metachromatic cells of pancreatic islets. / Solcia, Enrico; Sampietro, Roberto.

In: Zeitschrift für Zellforschung und Mikroskopische Anatomie, Vol. 65, No. 1, 01.1964, p. 131-138.

Research output: Contribution to journalArticle

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