Abstract
Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
Original language | English |
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Pages (from-to) | 2339-2342 |
Number of pages | 4 |
Journal | Journal of Neurophysiology |
Volume | 108 |
Issue number | 9 |
DOIs | |
Publication status | Published - Nov 1 2012 |
Keywords
- fMRI
- Negative BOLD response
- Neurovascular coupling
- Vascular steal
ASJC Scopus subject areas
- Physiology
- Neuroscience(all)