On the origin of sustained negative BOLD response

Marta Moraschi, Mauro DiNuzzo, Federico Giove

Research output: Contribution to journalArticlepeer-review


Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.

Original languageEnglish
Pages (from-to)2339-2342
Number of pages4
JournalJournal of Neurophysiology
Issue number9
Publication statusPublished - Nov 1 2012


  • fMRI
  • Negative BOLD response
  • Neurovascular coupling
  • Vascular steal

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)


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