Abstract
Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
| Original language | English |
|---|---|
| Pages (from-to) | 2339-2342 |
| Number of pages | 4 |
| Journal | Journal of Neurophysiology |
| Volume | 108 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 1 2012 |
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Keywords
- fMRI
- Negative BOLD response
- Neurovascular coupling
- Vascular steal
ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
Cite this
On the origin of sustained negative BOLD response. / Moraschi, Marta; DiNuzzo, Mauro; Giove, Federico.
In: Journal of Neurophysiology, Vol. 108, No. 9, 01.11.2012, p. 2339-2342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On the origin of sustained negative BOLD response
AU - Moraschi, Marta
AU - DiNuzzo, Mauro
AU - Giove, Federico
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
AB - Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
KW - fMRI
KW - Negative BOLD response
KW - Neurovascular coupling
KW - Vascular steal
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UR - http://www.scopus.com/inward/citedby.url?scp=84868313312&partnerID=8YFLogxK
U2 - 10.1152/jn.01199.2011
DO - 10.1152/jn.01199.2011
M3 - Article
C2 - 22723671
AN - SCOPUS:84868313312
VL - 108
SP - 2339
EP - 2342
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 9
ER -