On the origin of sustained negative BOLD response

Marta Moraschi, Mauro DiNuzzo, Federico Giove

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.

Original languageEnglish
Pages (from-to)2339-2342
Number of pages4
JournalJournal of Neurophysiology
Volume108
Issue number9
DOIs
Publication statusPublished - Nov 1 2012

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Blood Vessels
Primates
Magnetic Resonance Imaging
Brain

Keywords

  • fMRI
  • Negative BOLD response
  • Neurovascular coupling
  • Vascular steal

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

On the origin of sustained negative BOLD response. / Moraschi, Marta; DiNuzzo, Mauro; Giove, Federico.

In: Journal of Neurophysiology, Vol. 108, No. 9, 01.11.2012, p. 2339-2342.

Research output: Contribution to journalArticle

Moraschi, Marta ; DiNuzzo, Mauro ; Giove, Federico. / On the origin of sustained negative BOLD response. In: Journal of Neurophysiology. 2012 ; Vol. 108, No. 9. pp. 2339-2342.
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