On the pathophysiology of vitiligo: Possible treatment options

Research output: Contribution to journalArticlepeer-review

Abstract

Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalIndian Journal of Dermatology, Venereology and Leprology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Pathogenesis
  • treatment options
  • vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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