Abstract
Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.
| Original language | English |
|---|---|
| Pages (from-to) | 24-29 |
| Number of pages | 6 |
| Journal | Indian Journal of Dermatology, Venereology and Leprology |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2012 |
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Keywords
- Pathogenesis
- treatment options
- vitiligo
ASJC Scopus subject areas
- Dermatology
- Infectious Diseases
Cite this
On the pathophysiology of vitiligo : Possible treatment options. / Boissy, Raymond E.; Dell'anna, Maria Lucia; Picardo, Mauro.
In: Indian Journal of Dermatology, Venereology and Leprology, Vol. 78, No. 1, 01.2012, p. 24-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On the pathophysiology of vitiligo
T2 - Possible treatment options
AU - Boissy, Raymond E.
AU - Dell'anna, Maria Lucia
AU - Picardo, Mauro
PY - 2012/1
Y1 - 2012/1
N2 - Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.
AB - Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.
KW - Pathogenesis
KW - treatment options
KW - vitiligo
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UR - http://www.scopus.com/inward/citedby.url?scp=84861054601&partnerID=8YFLogxK
U2 - 10.4103/0378-6323.90943
DO - 10.4103/0378-6323.90943
M3 - Article
VL - 78
SP - 24
EP - 29
JO - Indian Journal of Dermatology, Venereology and Leprology
JF - Indian Journal of Dermatology, Venereology and Leprology
SN - 0378-6323
IS - 1
ER -