On the possibility of low cost, adherent therapeutic drug monitoring in oncology

Silvia Dalla Marta, Stefano Fornasaro, Aleksandra Jaworska, Giuseppe Toffoli, Alois Bonifacio, Valter Sergo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.

Original languageEnglish
Title of host publicationBiophotonics: Photonic Solutions for Better Health Care V
PublisherSPIE
Volume9887
ISBN (Electronic)9781510601321
DOIs
Publication statusPublished - 2016
EventBiophotonics: Photonic Solutions for Better Health Care V - Brussels, Belgium
Duration: Apr 4 2016Apr 7 2016

Other

OtherBiophotonics: Photonic Solutions for Better Health Care V
CountryBelgium
CityBrussels
Period4/4/164/7/16

Fingerprint

Oncology
Drugs
irinotecan
drugs
Spectroscopy
Monitoring
Quantification
Chemotherapy
Liquid chromatography
Pharmaceutical Preparations
Gas chromatography
Surface-enhanced Raman Scattering
Raman scattering
Costs
Repeatability
Cytotoxins
liquid chromatography
chemotherapy
gas chromatography
Selectivity

Keywords

  • Paper substrate
  • SERS
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics

Cite this

Dalla Marta, S., Fornasaro, S., Jaworska, A., Toffoli, G., Bonifacio, A., & Sergo, V. (2016). On the possibility of low cost, adherent therapeutic drug monitoring in oncology. In Biophotonics: Photonic Solutions for Better Health Care V (Vol. 9887). [98870G] SPIE. https://doi.org/10.1117/12.2225232

On the possibility of low cost, adherent therapeutic drug monitoring in oncology. / Dalla Marta, Silvia; Fornasaro, Stefano; Jaworska, Aleksandra; Toffoli, Giuseppe; Bonifacio, Alois; Sergo, Valter.

Biophotonics: Photonic Solutions for Better Health Care V. Vol. 9887 SPIE, 2016. 98870G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dalla Marta, S, Fornasaro, S, Jaworska, A, Toffoli, G, Bonifacio, A & Sergo, V 2016, On the possibility of low cost, adherent therapeutic drug monitoring in oncology. in Biophotonics: Photonic Solutions for Better Health Care V. vol. 9887, 98870G, SPIE, Biophotonics: Photonic Solutions for Better Health Care V, Brussels, Belgium, 4/4/16. https://doi.org/10.1117/12.2225232
Dalla Marta S, Fornasaro S, Jaworska A, Toffoli G, Bonifacio A, Sergo V. On the possibility of low cost, adherent therapeutic drug monitoring in oncology. In Biophotonics: Photonic Solutions for Better Health Care V. Vol. 9887. SPIE. 2016. 98870G https://doi.org/10.1117/12.2225232
Dalla Marta, Silvia ; Fornasaro, Stefano ; Jaworska, Aleksandra ; Toffoli, Giuseppe ; Bonifacio, Alois ; Sergo, Valter. / On the possibility of low cost, adherent therapeutic drug monitoring in oncology. Biophotonics: Photonic Solutions for Better Health Care V. Vol. 9887 SPIE, 2016.
@inproceedings{eef724fa7c234268894e7f43094b91bc,
title = "On the possibility of low cost, adherent therapeutic drug monitoring in oncology",
abstract = "A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.",
keywords = "Paper substrate, SERS, Therapeutic drug monitoring",
author = "{Dalla Marta}, Silvia and Stefano Fornasaro and Aleksandra Jaworska and Giuseppe Toffoli and Alois Bonifacio and Valter Sergo",
year = "2016",
doi = "10.1117/12.2225232",
language = "English",
volume = "9887",
booktitle = "Biophotonics: Photonic Solutions for Better Health Care V",
publisher = "SPIE",
address = "United States",

}

TY - GEN

T1 - On the possibility of low cost, adherent therapeutic drug monitoring in oncology

AU - Dalla Marta, Silvia

AU - Fornasaro, Stefano

AU - Jaworska, Aleksandra

AU - Toffoli, Giuseppe

AU - Bonifacio, Alois

AU - Sergo, Valter

PY - 2016

Y1 - 2016

N2 - A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.

AB - A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.

KW - Paper substrate

KW - SERS

KW - Therapeutic drug monitoring

UR - http://www.scopus.com/inward/record.url?scp=84982274223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982274223&partnerID=8YFLogxK

U2 - 10.1117/12.2225232

DO - 10.1117/12.2225232

M3 - Conference contribution

AN - SCOPUS:84982274223

VL - 9887

BT - Biophotonics: Photonic Solutions for Better Health Care V

PB - SPIE

ER -