On the possibility of low cost, adherent therapeutic drug monitoring in oncology

Silvia Dalla Marta, Stefano Fornasaro, Aleksandra Jaworska, Giuseppe Toffoli, Alois Bonifacio, Valter Sergo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.

Original languageEnglish
Title of host publicationBiophotonics: Photonic Solutions for Better Health Care V
PublisherSPIE
Volume9887
ISBN (Electronic)9781510601321
DOIs
Publication statusPublished - 2016
EventBiophotonics: Photonic Solutions for Better Health Care V - Brussels, Belgium
Duration: Apr 4 2016Apr 7 2016

Other

OtherBiophotonics: Photonic Solutions for Better Health Care V
CountryBelgium
CityBrussels
Period4/4/164/7/16

Keywords

  • Paper substrate
  • SERS
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics

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  • Cite this

    Dalla Marta, S., Fornasaro, S., Jaworska, A., Toffoli, G., Bonifacio, A., & Sergo, V. (2016). On the possibility of low cost, adherent therapeutic drug monitoring in oncology. In Biophotonics: Photonic Solutions for Better Health Care V (Vol. 9887). [98870G] SPIE. https://doi.org/10.1117/12.2225232