On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3

Claudio Costantini, Alessandra Micheletti, Federica Calzetti, Omar Perbellini, Nicola Tamassia, Cristina Albanesi, William Vermi, Marco A. Cassatella

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Interaction between neutrophils and other leukocytes plays a variety of important roles in regulating innate and adaptive immune responses. Recently, we have shown that neutrophils amplify NK cell/6-sulfo LacNAc+ dendritic cells (slanDC)-mediated cytokine production, by potentiating IL- 12p70 release by slanDC via CD18/ICAM-1 and directly costimulating IFNγ production by NK cells via ICAM-3. Herein, we have identified additional molecules involved in the interactions among neutrophils, NK cells and slanDC. More specifically, we provide evidence that: i) the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively; ii) slanDC potentiate the production of IFNγ by NK cells via CD11a/CD18. Altogether, our studies shed more light on the role that adhesion molecules play within the neutrophil/NK cell/slanDC network. Our data also have potential implications in the pathogenesis of diseases driven by hyperactivated leukocytes, such as Sweet's syndrome, in which a neutrophil/NK cell co-localization is frequently observed.

Original languageEnglish
Pages (from-to)1543-1547
Number of pages5
JournalHaematologica
Volume96
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Cell Adhesion Molecules
Cell Communication
Natural Killer Cells
Interferons
Neutrophils
Dendritic Cells
Leukocytes
Sweet Syndrome
Adaptive Immunity
Intercellular Adhesion Molecule-1
Innate Immunity
6-sulfo-LacNac
Cytokines

Keywords

  • CD11d
  • IFNγ
  • Neutrophil
  • NK cell
  • SlanDC
  • Sweet's syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3. / Costantini, Claudio; Micheletti, Alessandra; Calzetti, Federica; Perbellini, Omar; Tamassia, Nicola; Albanesi, Cristina; Vermi, William; Cassatella, Marco A.

In: Haematologica, Vol. 96, No. 10, 10.2011, p. 1543-1547.

Research output: Contribution to journalArticle

Costantini, Claudio ; Micheletti, Alessandra ; Calzetti, Federica ; Perbellini, Omar ; Tamassia, Nicola ; Albanesi, Cristina ; Vermi, William ; Cassatella, Marco A. / On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3. In: Haematologica. 2011 ; Vol. 96, No. 10. pp. 1543-1547.
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