On the proteolytic inhibitory effect of human foetal and neoplastic tissues

Pier Maria Fornasari, Maurizio Pandolfi, Birger Åstedt

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The protease inhibitory activity of different tissues was studied with a histochemical technique using fibrin as a substrate (fibrin slide sandwich technique). Human foetal tissues, placenta, decidua and tumoural (ovarian cancers with peritoneal metastases) tissues were examined. Strong inhibitory activity was found in thymus, placenta and decidua. The inhibitory activity of liver, pancreas, adrenals, spleen and ovarian cancer was moderate, while that of myocardium and kidney cortex was only weak. No such activity was found in lung, stomach, kidney medulla or peritoneal metastases. The presence of a protease inhibitor in the thymus was hitherto unknown.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalThrombosis Research
Volume8
Issue number6
DOIs
Publication statusPublished - 1976

Fingerprint

Decidua
Fibrin
Ovarian Neoplasms
Thymus Gland
Placenta
Splenic Neoplasms
Fetus
Adrenal Gland Neoplasms
Kidney Medulla
Neoplasm Metastasis
Kidney Cortex
Liver Neoplasms
Protease Inhibitors
Pancreatic Neoplasms
Stomach
Myocardium
Peptide Hydrolases
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

On the proteolytic inhibitory effect of human foetal and neoplastic tissues. / Fornasari, Pier Maria; Pandolfi, Maurizio; Åstedt, Birger.

In: Thrombosis Research, Vol. 8, No. 6, 1976, p. 829-836.

Research output: Contribution to journalArticle

Fornasari, Pier Maria ; Pandolfi, Maurizio ; Åstedt, Birger. / On the proteolytic inhibitory effect of human foetal and neoplastic tissues. In: Thrombosis Research. 1976 ; Vol. 8, No. 6. pp. 829-836.
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