Abstract
The protease inhibitory activity of different tissues was studied with a histochemical technique using fibrin as a substrate (fibrin slide sandwich technique). Human foetal tissues, placenta, decidua and tumoural (ovarian cancers with peritoneal metastases) tissues were examined. Strong inhibitory activity was found in thymus, placenta and decidua. The inhibitory activity of liver, pancreas, adrenals, spleen and ovarian cancer was moderate, while that of myocardium and kidney cortex was only weak. No such activity was found in lung, stomach, kidney medulla or peritoneal metastases. The presence of a protease inhibitor in the thymus was hitherto unknown.
| Original language | English |
|---|---|
| Pages (from-to) | 829-836 |
| Number of pages | 8 |
| Journal | Thrombosis Research |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology
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On the proteolytic inhibitory effect of human foetal and neoplastic tissues. / Fornasari, Pier Maria; Pandolfi, Maurizio; Åstedt, Birger.
In: Thrombosis Research, Vol. 8, No. 6, 1976, p. 829-836.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - On the proteolytic inhibitory effect of human foetal and neoplastic tissues
AU - Fornasari, Pier Maria
AU - Pandolfi, Maurizio
AU - Åstedt, Birger
PY - 1976
Y1 - 1976
N2 - The protease inhibitory activity of different tissues was studied with a histochemical technique using fibrin as a substrate (fibrin slide sandwich technique). Human foetal tissues, placenta, decidua and tumoural (ovarian cancers with peritoneal metastases) tissues were examined. Strong inhibitory activity was found in thymus, placenta and decidua. The inhibitory activity of liver, pancreas, adrenals, spleen and ovarian cancer was moderate, while that of myocardium and kidney cortex was only weak. No such activity was found in lung, stomach, kidney medulla or peritoneal metastases. The presence of a protease inhibitor in the thymus was hitherto unknown.
AB - The protease inhibitory activity of different tissues was studied with a histochemical technique using fibrin as a substrate (fibrin slide sandwich technique). Human foetal tissues, placenta, decidua and tumoural (ovarian cancers with peritoneal metastases) tissues were examined. Strong inhibitory activity was found in thymus, placenta and decidua. The inhibitory activity of liver, pancreas, adrenals, spleen and ovarian cancer was moderate, while that of myocardium and kidney cortex was only weak. No such activity was found in lung, stomach, kidney medulla or peritoneal metastases. The presence of a protease inhibitor in the thymus was hitherto unknown.
UR - http://www.scopus.com/inward/record.url?scp=0017170654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017170654&partnerID=8YFLogxK
U2 - 10.1016/0049-3848(76)90011-6
DO - 10.1016/0049-3848(76)90011-6
M3 - Article
C2 - 134463
AN - SCOPUS:0017170654
VL - 8
SP - 829
EP - 836
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 6
ER -