On the relationship between human papilloma virus vaccine and autoimmune diseases

Paolo Pellegrino, Carla Carnovale, Marco Pozzi, Stefania Antoniazzi, Valentina Perrone, Dionigi Salvati, Marta Gentili, Tatiana Brusadelli, Emilio Clementi, Sonia Radice

Research output: Contribution to journalArticle

Abstract

The human papilloma virus (HPV) vaccines were introduced to reduce the incidence of cervical cancer. The bivalent vaccine is effective against HPV-16, -18, -31, -33 and -45 while the quadrivalent vaccine is effective against HPV-16, 18, 31, 6 and 11 types. The immunisation, recommended for adolescent females, has led to high vaccine coverage in many countries.Along with the introduction of the HPV vaccines, several cases of onset or exacerbations of autoimmune diseases following the vaccine shot have been reported in the literature and pharmacovigilance databases, triggering concerns about its safety. This vaccination programme, however, has been introduced in a population that is at high risk for the onset of autoimmune diseases, making it difficult to assess the role of HPV vaccine in these cases and no conclusive studies have been reported thus far.We have thus analysed and reviewed comprehensively all case reports and studies dealing with either the onset of an autoimmune disease in vaccinated subject or the safety in patients with autoimmune diseases to define the role of the HPV vaccines in these diseases and hence its safety. A solid evidence of causal relationship was provided in few cases in the examined studies, and the risk vs. benefit of vaccination is still to be solved. The on-going vigilance for the safety of this vaccine remains thus of paramount importance.

Original languageEnglish
Pages (from-to)736-741
Number of pages6
JournalAutoimmunity Reviews
Volume13
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • Acute disseminated encephalomyelitis
  • Autoimmunity diseases
  • Human papilloma virus vaccine
  • Juvenile idiopathic arthritis
  • Multiple sclerosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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  • Cite this

    Pellegrino, P., Carnovale, C., Pozzi, M., Antoniazzi, S., Perrone, V., Salvati, D., Gentili, M., Brusadelli, T., Clementi, E., & Radice, S. (2014). On the relationship between human papilloma virus vaccine and autoimmune diseases. Autoimmunity Reviews, 13(7), 736-741. https://doi.org/10.1016/j.autrev.2014.01.054