On the reorganization of sensory hand areas after mono-hemispheric lesion

A functional (MEG)/anatomical (MRI) integrarive study

P. M. Rossini, F. Tecchio, V. Pizzella, D. Lupoi, E. Cassetta, P. Pasqualetti, G. L. Romani, A. Orlacchio

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The topography of primary sensory cortical hand area following a monohemispheric lesion (sudden = stroke; progressive = neoplasm) was investigated in relationship with clinical recovery of sensorimotor deficits. Twenty seven patients with monohemispheric lesions were studied in a clinically stabilized condition. Functional informations from magnetoencephalography (MEG) were integrated with anatomical data from magnetic resonance imaging (MRI). MEG localizations of the neurons firing at early latencies in primary sensory cortex after separate stimulation of median nerve, thumb and little fingers of each hand were carried out. Characteristics of cerebral equivalent current dipoles (ECDs) activated by each contralateral stimulation, the 'hand extension' (i.e., the distance in millimetres between ECDs of first and fifth digits), as well as interhemispheric differences of the tested parameters were investigated. Finally, ECDs' locations were integrated with MRI. Lesions involving cortical (C) or subcortical (SC) areas receiving sensory input from the hand were often combined to increase interhemispheric asymmetry of the tested parameters (22% for C and 49% for SC lesions). This might be due to an activation of neuronal districts which in the affected hemisphere (AH) differ from those normally activated in the unaffected hemisphere (UH) and in the control population. Moreover, the 'hand extension' was enlarged on the AH- more frequently after a SC lesion - mainly due to a medial shift of the little finger ECD, combined to a tendency of both finger ECDs to shift frontally. After a C lesion, responses from the AH were often stronger than normal. Spatial reorganizations were also seen in the UH (7% of C and 14% of SC lesions). 'Hand extension' in the UH was selectively enlarged for the P30m only when combined with a similar enlargement in the AH. Significant interhemispheric asymmetries due to neuronal reorganization in the AH were associated with worse clinical outcomes compared to patients without asymmetries.

Original languageEnglish
Pages (from-to)153-166
Number of pages14
JournalBrain Research
Volume782
Issue number1-2
DOIs
Publication statusPublished - Jan 26 1998

Fingerprint

Magnetoencephalography
Hand
Magnetic Resonance Imaging
Fingers
Median Nerve
Thumb
Stroke
Neurons
Population
Neoplasms

Keywords

  • Hand cortical representation
  • Hemispheric lesion
  • Magnetic resonance imaging
  • Neuromagnetism
  • Plastic reorganization
  • Somatosensory evoked field

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

On the reorganization of sensory hand areas after mono-hemispheric lesion : A functional (MEG)/anatomical (MRI) integrarive study. / Rossini, P. M.; Tecchio, F.; Pizzella, V.; Lupoi, D.; Cassetta, E.; Pasqualetti, P.; Romani, G. L.; Orlacchio, A.

In: Brain Research, Vol. 782, No. 1-2, 26.01.1998, p. 153-166.

Research output: Contribution to journalArticle

Rossini, P. M. ; Tecchio, F. ; Pizzella, V. ; Lupoi, D. ; Cassetta, E. ; Pasqualetti, P. ; Romani, G. L. ; Orlacchio, A. / On the reorganization of sensory hand areas after mono-hemispheric lesion : A functional (MEG)/anatomical (MRI) integrarive study. In: Brain Research. 1998 ; Vol. 782, No. 1-2. pp. 153-166.
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