TY - JOUR
T1 - On the role of central type-1 Cannabinoid receptor gene regulation in food intake and eating behaviors
AU - Pucci, Mariangela
AU - Zaplatic, Elizabeta
AU - Di Bonaventura, Maria Vittoria Micioni
AU - Di Bonaventura, Emanuela Micioni
AU - De Cristofaro, Paolo
AU - Maccarrone, Mauro
AU - Cifani, Carlo
AU - D’Addario, Claudio
N1 - Funding Information:
Funding: This research was funded by Marie Skłodowska-Curie grant agreement no. 713714 (RepEat—H2020-MSCACOFUND-2015) and partially by a grant from the Italian Ministry of Education, University and Research (PRIN2015KP7T2Y) to C.C. Partial support by the EU-LAC (European LatinoAmerican Countries) Foundation under competitive grant EULAC16/T01-0132 to MM is also gratefully acknowledged. The EU-LAC Foundation had no role in the design or conduct of the study.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Different neuromodulatory systems are involved in long- term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.
AB - Different neuromodulatory systems are involved in long- term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.
KW - Eating behaviors
KW - Food intake
KW - Transcriptional regulation
KW - Type-1 cannabinoid receptor gene
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U2 - 10.3390/ijms22010398
DO - 10.3390/ijms22010398
M3 - Article
C2 - 33401515
AN - SCOPUS:85098786440
VL - 22
SP - 1
EP - 16
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 1
M1 - 398
ER -