A tridecapeptide with the sequence CCEICCNPACFGC has been synthesized to reproduce the active moiety of a heat stable enterotoxin from Vibrio cholerae. The proton NMR analysis indicates, for the active synthetic fragment, a rigid secondary structure stabilised by three disulfide bridges. Such a rigid peptide, suitably detoxified and activated, could be a good candidate to be used as a carrier for linear bioactive peptides or other functional groups.
|Number of pages||7|
|Journal||Journal of Biomolecular Structure and Dynamics|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Molecular Biology
- Structural Biology