TY - JOUR
T1 - On the structural stability of a small bioactive peptide of potential use in biotechnology
AU - Di Maro, Daniela
AU - Scarselli, Maria
AU - Bernini, Andrea
AU - Cresti, Stefania
AU - Rossolini, Gian Maria
AU - Lozzi, Luisa
AU - Neri, Paolo
AU - Niccolai, Neri
PY - 1999
Y1 - 1999
N2 - A tridecapeptide with the sequence CCEICCNPACFGC has been synthesized to reproduce the active moiety of a heat stable enterotoxin from Vibrio cholerae. The proton NMR analysis indicates, for the active synthetic fragment, a rigid secondary structure stabilised by three disulfide bridges. Such a rigid peptide, suitably detoxified and activated, could be a good candidate to be used as a carrier for linear bioactive peptides or other functional groups.
AB - A tridecapeptide with the sequence CCEICCNPACFGC has been synthesized to reproduce the active moiety of a heat stable enterotoxin from Vibrio cholerae. The proton NMR analysis indicates, for the active synthetic fragment, a rigid secondary structure stabilised by three disulfide bridges. Such a rigid peptide, suitably detoxified and activated, could be a good candidate to be used as a carrier for linear bioactive peptides or other functional groups.
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M3 - Article
C2 - 10333175
AN - SCOPUS:0032946336
VL - 16
SP - 1053
EP - 1059
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
SN - 0739-1102
IS - 5
ER -