Onclarity Human Papillomavirus Extended Genotyping in the Management of Cervical Intraepithelial Neoplasia 2+ Lesions: Journal of Lower Genital Tract Disease

F. Bottari, A.D. Iacobone, S. Boveri, E.P. Preti, D. Franchi, L. Mariani, M. Preti, F. Landoni, R. Passerini, M.T. Sandri

Research output: Contribution to journalArticle

Abstract

Objective Many methods are available today for human papillomavirus (HPV) testing; they differ for technology, targets, and information on the genotypes detected. In this study, we evaluated the performance of the Onclarity HPV assay in detection and follow-up of cervical preneoplastic lesions. Materials and Methods One hundred sixty-seven women referred to the European Institute of Oncology, Milan, for treatment of cervical lesions were enrolled. We investigated the utility of Onclarity extended genotyping HPV test in the management of cervical intraepithelial neoplasia (CIN) 2+ preneoplastic lesion. Results At baseline, the concordance was 92% (150/163) between Onclarity and Hybrid Capture 2 (HC2) and 93% (142/152) between Onclarity and linear array, respectively. At follow-up, the concordance between Onclarity and HC2 was 80%. Seven women relapsed: 6 had persistence of the same genotypes and 1 patient tested negative not only with Onclarity but also with HC2 for the presence of a low-risk genotype in the sample. Conclusions This study showed that the evaluation of the HPV genotype persistence may represent a valid option to monitor patients treated for CIN 2+ lesions, because relapses were detected only in patients with persistence of the same genotype detected at baseline. © Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalJ. Lower Genital Tract Dis.
Volume23
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • cervical intraepithelial neoplasia
  • follow-up
  • HPV
  • real-time polymerase chain reaction genotyping
  • adult
  • Article
  • cancer patient
  • cancer recurrence
  • controlled study
  • female
  • follow up
  • genotype
  • human
  • human tissue
  • low risk population
  • major clinical study
  • uterine cervix carcinoma in situ
  • classification
  • complication
  • disease management
  • evaluation study
  • genetics
  • genotyping technique
  • isolation and purification
  • Italy
  • middle aged
  • molecular diagnosis
  • Papillomaviridae
  • papillomavirus infection
  • procedures
  • prospective study
  • recurrent disease
  • virology
  • Adult
  • Cervical Intraepithelial Neoplasia
  • Disease Management
  • Female
  • Genotype
  • Genotyping Techniques
  • Humans
  • Middle Aged
  • Molecular Diagnostic Techniques
  • Papillomavirus Infections
  • Prospective Studies
  • Recurrence

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