Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number

Gianluca Marucci, Alessandra Maresca, Leonardo Caporali, Anna Farnedi, Christine Margaret Betts, Luca Morandi, Dario De Biase, Serenella Cerasoli, Maria Pia Foschini, Elena Bonora, Michele Vidone, Giovanni Romeo, Elena Perli, Carla Giordano, Giulia D'Amati, Giuseppe Gasparre, Agostino Baruzzi, Valerio Carelli, Vincenzo Eusebi

Research output: Contribution to journalArticlepeer-review

Abstract

Ten cases of glioblastomas showing oncocytic changes are described. The tumors showed mononuclear to multinuclear cells and abundant, granular, eosinophilic cytoplasm. The cytoplasm of these same cells was filled by strongly immunoreactive mitochondria. At ultrastructure, numerous mitochondria, some of which were large, were evidenced in the cytoplasm of neoplastic cells. Finally, 9 of 10 of these cases had a significantly high mitochondrial DNA content compared with control tissue (P

Original languageEnglish
Pages (from-to)1867-1876
Number of pages10
JournalHuman Pathology
Volume44
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Glioblastoma
  • mtDNA
  • Oncocytic features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number'. Together they form a unique fingerprint.

Cite this