We investigated the structure and the expression of various oncogenes in three of the most common human bone tumors-steosarcoma (36 samples from 34 patients), giant cell tumor (10 patients), and chondrosarcoma (18 patients)- in an attempt to identify the genetic alterations associated with these malignancies. Alterations of RB and p53 were detected only in osteosarcomas. Alterations of c-myc, N-myc, and c-fos were detected in osteosarcomas and giant cell tumors. Ras alterations (H-ras, Ki-ras, N-ras) were rare. Chondrosarcomas did not contain any detectable genetic alterations. Our results suggest that alterations of c-myc, N-myc, and c-fos oncogenes occur in osteosarcomas, in addition to those previously described for the tumor suppressor genes RB and p53. Moreover, statistical analyses indicate that c- fos alterations occur more frequently in osteosarcoma patients with recurrent or metastatic disease.
|Number of pages||14|
|Journal||Journal of Cellular Biochemistry|
|Publication status||Published - Oct 1996|
- oncogene alterations
ASJC Scopus subject areas
- Cell Biology