Oncogene alterations in primary, recurrent, and metastatic human bone tumors

Franca Pompetti, Paola Rizzo, Richard M. Simon, Boris Freidlin, Daphne J. Mew, Harvey I. Pass, Piero Picci, Arthur S. Levine, Michele Carbone

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We investigated the structure and the expression of various oncogenes in three of the most common human bone tumors-steosarcoma (36 samples from 34 patients), giant cell tumor (10 patients), and chondrosarcoma (18 patients)- in an attempt to identify the genetic alterations associated with these malignancies. Alterations of RB and p53 were detected only in osteosarcomas. Alterations of c-myc, N-myc, and c-fos were detected in osteosarcomas and giant cell tumors. Ras alterations (H-ras, Ki-ras, N-ras) were rare. Chondrosarcomas did not contain any detectable genetic alterations. Our results suggest that alterations of c-myc, N-myc, and c-fos oncogenes occur in osteosarcomas, in addition to those previously described for the tumor suppressor genes RB and p53. Moreover, statistical analyses indicate that c- fos alterations occur more frequently in osteosarcoma patients with recurrent or metastatic disease.

Original languageEnglish
Pages (from-to)37-50
Number of pages14
JournalJournal of Cellular Biochemistry
Issue number1
Publication statusPublished - Oct 1996



  • chondrosarcoma
  • GCT
  • oncogene alterations
  • osteosarcoma

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Pompetti, F., Rizzo, P., Simon, R. M., Freidlin, B., Mew, D. J., Pass, H. I., Picci, P., Levine, A. S., & Carbone, M. (1996). Oncogene alterations in primary, recurrent, and metastatic human bone tumors. Journal of Cellular Biochemistry, 63(1), 37-50. https://doi.org/10.1002/(SICI)1097-4644(199610)63:1<37::AID-JCB3>3.0.CO;2-0