Oncogenic MicroRNAs: Key players in malignant transformation

Tania Frixa, Sara Donzelli, Giovanni Blandino

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

Original languageEnglish
Pages (from-to)2466-2485
Number of pages20
JournalCancers
Volume7
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

MicroRNAs
Biological Phenomena
Untranslated RNA
Gene Expression Regulation
Neoplasms
Carcinogenesis
Neoplasm Metastasis

Keywords

  • Apoptosis
  • Cancer
  • Cell cycle regulation
  • Oncogenic miRNAs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Oncogenic MicroRNAs : Key players in malignant transformation. / Frixa, Tania; Donzelli, Sara; Blandino, Giovanni.

In: Cancers, Vol. 7, No. 4, 2015, p. 2466-2485.

Research output: Contribution to journalArticle

Frixa, Tania ; Donzelli, Sara ; Blandino, Giovanni. / Oncogenic MicroRNAs : Key players in malignant transformation. In: Cancers. 2015 ; Vol. 7, No. 4. pp. 2466-2485.
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