Abstract
MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.
Original language | English |
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Pages (from-to) | 2466-2485 |
Number of pages | 20 |
Journal | Cancers |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Apoptosis
- Cancer
- Cell cycle regulation
- Oncogenic miRNAs
ASJC Scopus subject areas
- Oncology
- Cancer Research