Oncogenic MicroRNAs: Key players in malignant transformation

Tania Frixa; Sara Donzelli; Giovanni Blandino

doi:10.3390/cancers7040904

Oncogenic MicroRNAs: Key players in malignant transformation

Tania Frixa, Sara Donzelli, Giovanni Blandino

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

Original language	English
Pages (from-to)	2466-2485
Number of pages	20
Journal	Cancers
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/cancers7040904
Publication status	Published - 2015

Keywords

Apoptosis
Cancer
Cell cycle regulation
Oncogenic miRNAs

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers7040904

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