Oncogenic MicroRNAs: Key players in malignant transformation

Tania Frixa; Sara Donzelli; Giovanni Blandino

doi:10.3390/cancers7040904

Oncogenic MicroRNAs: Key players in malignant transformation

Tania Frixa, Sara Donzelli, Giovanni Blandino

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

Original language	English
Pages (from-to)	2466-2485
Number of pages	20
Journal	Cancers
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/cancers7040904
Publication status	Published - 2015

Keywords

Apoptosis
Cancer
Cell cycle regulation
Oncogenic miRNAs

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.3390/cancers7040904

Cite this

@article{005bc5a75b2d423fbf02578b45e3e340,

title = "Oncogenic MicroRNAs: Key players in malignant transformation",

abstract = "MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.",

keywords = "Apoptosis, Cancer, Cell cycle regulation, Oncogenic miRNAs",

author = "Tania Frixa and Sara Donzelli and Giovanni Blandino",

year = "2015",

doi = "10.3390/cancers7040904",

language = "English",

volume = "7",

pages = "2466--2485",

journal = "Cancers",

issn = "2072-6694",

publisher = "MDPI AG",

number = "4",

}

TY - JOUR

T1 - Oncogenic MicroRNAs

T2 - Key players in malignant transformation

AU - Frixa, Tania

AU - Donzelli, Sara

AU - Blandino, Giovanni

PY - 2015

Y1 - 2015

N2 - MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

AB - MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.

KW - Apoptosis

KW - Cancer

KW - Cell cycle regulation

KW - Oncogenic miRNAs

UR - http://www.scopus.com/inward/record.url?scp=84951077095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951077095&partnerID=8YFLogxK

U2 - 10.3390/cancers7040904

DO - 10.3390/cancers7040904

M3 - Article

AN - SCOPUS:84951077095

VL - 7

SP - 2466

EP - 2485

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 4

ER -

Oncogenic MicroRNAs: Key players in malignant transformation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this