Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses

Giuseppe Guglielmi, Michele Bisceglia, Alfredo Scillitani, Andrew L. Folpe

Research output: Contribution to journalArticle

Abstract

Background: The phosphaturic mesenchymal tumor of the craniofacial sinuses (mixed connective tissue variant) is an extremely rare, distinctive paraneoplastic syndrome that is frequently associated with oncogenic osteomalacia. Methods: In this report is presented a case of 22 years old man indicated four years of progressive generalized pain and weakness, eventually becoming wheel-chair bound. His current presentation was for chest pain resulting from atraumatic rib fractures. Results: Imaging showed osteoporosis and multiple insufficiency fractures. CT and MRI showed an ethmoid mass. He had no symptoms referable to his nose or sinuses. Conclusions: The ethmoid lesion was completely excised, the patient's laboratory parameters returned to normal levels and the patient's symptoms disappeared.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalClinical Cases in Mineral and Bone Metabolism
Volume8
Issue number2
Publication statusPublished - May 2011

Keywords

  • Diagnostic imaging
  • Insufficiency fracture
  • Oncogenic osteomalacia
  • Phosphaturic mesenchymal tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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