Oncogenic Ras

A double-edged sword for human epidermal stem and transient amplifying cells

Research output: Contribution to journalReview article

Abstract

The human epidermal clonal evolution, i.e. the transition from stem cells (SCs) to transient amplifying (TA)-cells and post-mitotic cells, is a continuous and tightly regulated process that ensures physiologic tissue homeostasis. The Ras family of small GTPases has a key role in skin homeostasis and tumorigenesis. Indeed, activating mutations in Ras genes have been found in human cutaneous squamous cell carcinomas (cSCCs) and in experimentally-induced murine cSCCs. In mouse models, the Ras signaling might lead to hyperproliferative phenotypes, including the development of cSCCs, depending on the nature of the founding cells. Tumor-initiating cells or Cancer Stem Cells (CSCs) have been demonstrated in murine and human cSCCs even if the mechanism of their development from normal SCs or TA-cells is not completely elucidated. Here, the relation between the Ras expression outcome and the clonogenic potential of the target keratinocyte is discussed.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalSmall GTPases
Volume7
Issue number3
DOIs
Publication statusPublished - Jul 2 2016

Fingerprint

Stem cells
Squamous Cell Carcinoma
Skin
Neoplastic Stem Cells
Tissue homeostasis
Homeostasis
Stem Cells
Monomeric GTP-Binding Proteins
Clonal Evolution
ras Genes
Tumors
Keratinocytes
Genes
Carcinogenesis
Epithelial Cells
Phenotype
Mutation

Keywords

  • Bmi-1
  • cutaneous squamous cell carcinoma
  • human
  • keratinocytes
  • p16
  • p63
  • primary cultures
  • Ras
  • stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Oncogenic Ras : A double-edged sword for human epidermal stem and transient amplifying cells. / Dellambra, Elena.

In: Small GTPases, Vol. 7, No. 3, 02.07.2016, p. 147-155.

Research output: Contribution to journalReview article

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