TY - JOUR
T1 - Oncogenic virome benefits from the different vaginal microbiome-immune axes
AU - Campisciano, Giuseppina
AU - Gheit, Tarik
AU - De Seta, Francesco
AU - Cason, Carolina
AU - Zanotta, Nunzia
AU - Delbue, Serena
AU - Ricci, Giuseppe
AU - Ferrante, Pasquale
AU - Tommasino, Massimo
AU - Comar, Manola
PY - 2019/10
Y1 - 2019/10
N2 - The picture of dynamic interaction between oncogenic viruses and the vaginal bacteria-immune host milieu is incomplete. We evaluated the impact of Polyomaviridae, Papillomaviridae, and Herpesviridae oncoviruses on the vaginal Community State Types (CSTs) and host immune response in reproductive-age women. In our cohort, only Polyomaviridae and Papillomaviridae were detected and were associated with changes in the resident bacteria of CST I and IV (p < 0.05). Lactobacillus crispatus increased in CST I while Prevotella timonensis and Sneathia sanguinegens increased in CST IV. Conversely, CST II and III showed an alteration of the immune response, with the decrease of Eotaxin, MCP-1, IL-7, IL-9, and IL-15 (p < 0.05), leading to reduced antiviral efficacy. An efficient viral clearance was observed only in women from CST I, dominated by Lactobacillus crispatus. Our in vivo study begins to address the knowledge gap with respect to the role of vaginal bacteria and immune response in susceptibility to oncoviral infections.
AB - The picture of dynamic interaction between oncogenic viruses and the vaginal bacteria-immune host milieu is incomplete. We evaluated the impact of Polyomaviridae, Papillomaviridae, and Herpesviridae oncoviruses on the vaginal Community State Types (CSTs) and host immune response in reproductive-age women. In our cohort, only Polyomaviridae and Papillomaviridae were detected and were associated with changes in the resident bacteria of CST I and IV (p < 0.05). Lactobacillus crispatus increased in CST I while Prevotella timonensis and Sneathia sanguinegens increased in CST IV. Conversely, CST II and III showed an alteration of the immune response, with the decrease of Eotaxin, MCP-1, IL-7, IL-9, and IL-15 (p < 0.05), leading to reduced antiviral efficacy. An efficient viral clearance was observed only in women from CST I, dominated by Lactobacillus crispatus. Our in vivo study begins to address the knowledge gap with respect to the role of vaginal bacteria and immune response in susceptibility to oncoviral infections.
KW - Bacteriome
KW - Immune response
KW - Vagitypes
KW - Virome
UR - http://www.scopus.com/inward/record.url?scp=85074302231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074302231&partnerID=8YFLogxK
U2 - 10.3390/microorganisms7100414
DO - 10.3390/microorganisms7100414
M3 - Article
AN - SCOPUS:85074302231
VL - 7
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 10
M1 - 414
ER -