Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals

Francesco Bussu, Federica Mura, Francesco Miccichè, Giulia Bertino, Antonio Occhini, Giovanni Almadori, Jacopo Galli, Manlio Pandolfini, Roberto Gallus, Rosa Autorino, Maria Lavinia Guidi, Nicola Dinapoli, Vincenzo Valentini, Gaetano Paludetti, Marco Benazzo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities. Methods: The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed. The correlations of oncologic endpoints with tumor parameters and primary treatment were evaluated. Results: The overall survival (OS) rate was 76% and the disease-specific survival (DSS) rate was 80% at 3 years in the entire group. Sex and T and N classifications significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and radiotherapy (RT), and the temporal sequence of the 2 modalities did not affect prognosis. Conclusion: The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in univariate and multivariate analyses for any stage considered.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Squamous Cell Carcinoma
Carcinoma
Multivariate Analysis
Survival Rate
Hypopharynx
Medical Records
Radiotherapy
Therapeutics
Survival
Neoplasms
Carcinoma, squamous cell of head and neck

Keywords

  • Hypopharyngeal squamous cell carcinoma
  • Multidisciplinary approach
  • Primary treatment
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals. / Bussu, Francesco; Mura, Federica; Miccichè, Francesco; Bertino, Giulia; Occhini, Antonio; Almadori, Giovanni; Galli, Jacopo; Pandolfini, Manlio; Gallus, Roberto; Autorino, Rosa; Guidi, Maria Lavinia; Dinapoli, Nicola; Valentini, Vincenzo; Paludetti, Gaetano; Benazzo, Marco.

In: Head and Neck, 2015.

Research output: Contribution to journalArticle

Bussu, F, Mura, F, Miccichè, F, Bertino, G, Occhini, A, Almadori, G, Galli, J, Pandolfini, M, Gallus, R, Autorino, R, Guidi, ML, Dinapoli, N, Valentini, V, Paludetti, G & Benazzo, M 2015, 'Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals', Head and Neck. https://doi.org/10.1002/hed.23938
Bussu, Francesco ; Mura, Federica ; Miccichè, Francesco ; Bertino, Giulia ; Occhini, Antonio ; Almadori, Giovanni ; Galli, Jacopo ; Pandolfini, Manlio ; Gallus, Roberto ; Autorino, Rosa ; Guidi, Maria Lavinia ; Dinapoli, Nicola ; Valentini, Vincenzo ; Paludetti, Gaetano ; Benazzo, Marco. / Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals. In: Head and Neck. 2015.
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AU - Bussu, Francesco

AU - Mura, Federica

AU - Miccichè, Francesco

AU - Bertino, Giulia

AU - Occhini, Antonio

AU - Almadori, Giovanni

AU - Galli, Jacopo

AU - Pandolfini, Manlio

AU - Gallus, Roberto

AU - Autorino, Rosa

AU - Guidi, Maria Lavinia

AU - Dinapoli, Nicola

AU - Valentini, Vincenzo

AU - Paludetti, Gaetano

AU - Benazzo, Marco

PY - 2015

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N2 - Background: The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities. Methods: The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed. The correlations of oncologic endpoints with tumor parameters and primary treatment were evaluated. Results: The overall survival (OS) rate was 76% and the disease-specific survival (DSS) rate was 80% at 3 years in the entire group. Sex and T and N classifications significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and radiotherapy (RT), and the temporal sequence of the 2 modalities did not affect prognosis. Conclusion: The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in univariate and multivariate analyses for any stage considered.

AB - Background: The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities. Methods: The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed. The correlations of oncologic endpoints with tumor parameters and primary treatment were evaluated. Results: The overall survival (OS) rate was 76% and the disease-specific survival (DSS) rate was 80% at 3 years in the entire group. Sex and T and N classifications significantly influenced survival in both univariate and multivariate analyses. Seventy-four percent of our patients underwent both surgery and radiotherapy (RT), and the temporal sequence of the 2 modalities did not affect prognosis. Conclusion: The primary treatment modality in patients with resectable hypopharyngeal SCC did not affect prognosis in univariate and multivariate analyses for any stage considered.

KW - Hypopharyngeal squamous cell carcinoma

KW - Multidisciplinary approach

KW - Primary treatment

KW - Radiotherapy

KW - Surgery

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