Oncological results of immediate breast reconstruction: Long term follow-up of a large series at a single institution

J. Y. Petit, O. Gentilini, N. Rotmensz, P. Rey, M. Rietjens, C. Garusi, E. Botteri, F. De Lorenzi, S. Martella, R. Bosco, D. K. Khuthaila, A. Luini

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Abstract

Background: Reconstruction of the breast after mastectomy is an integral part of the complete management of breast cancer. However, a delay in the reconstruction is usually proposed after the mastectomy in case of invasive cancer, while there is a general agreement for immediate breast reconstruction in case of in situ tumors. Patients and methods: Among a total of 677 patients having undergone a mastectomy between 1997 and 2001, 518 (76.5%) underwent an immediate breast reconstruction (IBR). All the patients had a Patey mastectomy for invasive cancer (T1-T3). An adjuvant medical treatment was given according to the biological characteristics of the tumor and lymph node status. No patient received any kind of radiotherapy. The median follow up was 70 months (range 13-114). Results: The local recurrence rate was 5.2% for the group of IBR and 9.4% for the mastectomy group without IBR (NoIBR). The regional metastases rate was 1.4 vs. 1.3%. The rate of distant metastases was 13.9 vs. 16.4%. Contra-lateral breast tumor was observed in 1.5 vs. 1.3%. Death rate was 10.4 vs. 16.4%. No statistical difference was observed between the two groups in terme of overall survival (OS) and disease free survival (DFS) (HR IBR vs. NoIBR: 1.03 and 0.99 for OS and DFS, respectively). Conclusion: At our institution we have compared a large series that have undergone IBR (518) with a control group (159) and followed over a prolonged period of time (70 months). This study provides the best available results to suggest that IBR is a safe and reliable treatment option for the managing invasive breast cancer.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalBreast Cancer Research and Treatment
Volume112
Issue number3
DOIs
Publication statusPublished - Dec 2008

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Mammaplasty
Mastectomy
Breast Neoplasms
Disease-Free Survival
Neoplasms
Neoplasm Metastasis
Modified Radical Mastectomy
Survival
Radiotherapy
Lymph Nodes
Recurrence
Control Groups
Mortality
Therapeutics

Keywords

  • Immediate breast recontruction
  • Invasive breast cancer
  • Local recurrence
  • Mastectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

@article{b81ac88d76004ee0b46474bc61dcdff1,
title = "Oncological results of immediate breast reconstruction: Long term follow-up of a large series at a single institution",
abstract = "Background: Reconstruction of the breast after mastectomy is an integral part of the complete management of breast cancer. However, a delay in the reconstruction is usually proposed after the mastectomy in case of invasive cancer, while there is a general agreement for immediate breast reconstruction in case of in situ tumors. Patients and methods: Among a total of 677 patients having undergone a mastectomy between 1997 and 2001, 518 (76.5{\%}) underwent an immediate breast reconstruction (IBR). All the patients had a Patey mastectomy for invasive cancer (T1-T3). An adjuvant medical treatment was given according to the biological characteristics of the tumor and lymph node status. No patient received any kind of radiotherapy. The median follow up was 70 months (range 13-114). Results: The local recurrence rate was 5.2{\%} for the group of IBR and 9.4{\%} for the mastectomy group without IBR (NoIBR). The regional metastases rate was 1.4 vs. 1.3{\%}. The rate of distant metastases was 13.9 vs. 16.4{\%}. Contra-lateral breast tumor was observed in 1.5 vs. 1.3{\%}. Death rate was 10.4 vs. 16.4{\%}. No statistical difference was observed between the two groups in terme of overall survival (OS) and disease free survival (DFS) (HR IBR vs. NoIBR: 1.03 and 0.99 for OS and DFS, respectively). Conclusion: At our institution we have compared a large series that have undergone IBR (518) with a control group (159) and followed over a prolonged period of time (70 months). This study provides the best available results to suggest that IBR is a safe and reliable treatment option for the managing invasive breast cancer.",
keywords = "Immediate breast recontruction, Invasive breast cancer, Local recurrence, Mastectomy",
author = "Petit, {J. Y.} and O. Gentilini and N. Rotmensz and P. Rey and M. Rietjens and C. Garusi and E. Botteri and {De Lorenzi}, F. and S. Martella and R. Bosco and Khuthaila, {D. K.} and A. Luini",
year = "2008",
month = "12",
doi = "10.1007/s10549-008-9891-x",
language = "English",
volume = "112",
pages = "545--549",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York LLC",
number = "3",

}

TY - JOUR

T1 - Oncological results of immediate breast reconstruction

T2 - Long term follow-up of a large series at a single institution

AU - Petit, J. Y.

AU - Gentilini, O.

AU - Rotmensz, N.

AU - Rey, P.

AU - Rietjens, M.

AU - Garusi, C.

AU - Botteri, E.

AU - De Lorenzi, F.

AU - Martella, S.

AU - Bosco, R.

AU - Khuthaila, D. K.

AU - Luini, A.

PY - 2008/12

Y1 - 2008/12

N2 - Background: Reconstruction of the breast after mastectomy is an integral part of the complete management of breast cancer. However, a delay in the reconstruction is usually proposed after the mastectomy in case of invasive cancer, while there is a general agreement for immediate breast reconstruction in case of in situ tumors. Patients and methods: Among a total of 677 patients having undergone a mastectomy between 1997 and 2001, 518 (76.5%) underwent an immediate breast reconstruction (IBR). All the patients had a Patey mastectomy for invasive cancer (T1-T3). An adjuvant medical treatment was given according to the biological characteristics of the tumor and lymph node status. No patient received any kind of radiotherapy. The median follow up was 70 months (range 13-114). Results: The local recurrence rate was 5.2% for the group of IBR and 9.4% for the mastectomy group without IBR (NoIBR). The regional metastases rate was 1.4 vs. 1.3%. The rate of distant metastases was 13.9 vs. 16.4%. Contra-lateral breast tumor was observed in 1.5 vs. 1.3%. Death rate was 10.4 vs. 16.4%. No statistical difference was observed between the two groups in terme of overall survival (OS) and disease free survival (DFS) (HR IBR vs. NoIBR: 1.03 and 0.99 for OS and DFS, respectively). Conclusion: At our institution we have compared a large series that have undergone IBR (518) with a control group (159) and followed over a prolonged period of time (70 months). This study provides the best available results to suggest that IBR is a safe and reliable treatment option for the managing invasive breast cancer.

AB - Background: Reconstruction of the breast after mastectomy is an integral part of the complete management of breast cancer. However, a delay in the reconstruction is usually proposed after the mastectomy in case of invasive cancer, while there is a general agreement for immediate breast reconstruction in case of in situ tumors. Patients and methods: Among a total of 677 patients having undergone a mastectomy between 1997 and 2001, 518 (76.5%) underwent an immediate breast reconstruction (IBR). All the patients had a Patey mastectomy for invasive cancer (T1-T3). An adjuvant medical treatment was given according to the biological characteristics of the tumor and lymph node status. No patient received any kind of radiotherapy. The median follow up was 70 months (range 13-114). Results: The local recurrence rate was 5.2% for the group of IBR and 9.4% for the mastectomy group without IBR (NoIBR). The regional metastases rate was 1.4 vs. 1.3%. The rate of distant metastases was 13.9 vs. 16.4%. Contra-lateral breast tumor was observed in 1.5 vs. 1.3%. Death rate was 10.4 vs. 16.4%. No statistical difference was observed between the two groups in terme of overall survival (OS) and disease free survival (DFS) (HR IBR vs. NoIBR: 1.03 and 0.99 for OS and DFS, respectively). Conclusion: At our institution we have compared a large series that have undergone IBR (518) with a control group (159) and followed over a prolonged period of time (70 months). This study provides the best available results to suggest that IBR is a safe and reliable treatment option for the managing invasive breast cancer.

KW - Immediate breast recontruction

KW - Invasive breast cancer

KW - Local recurrence

KW - Mastectomy

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