Oncological results of oncoplastic breast-conserving surgery

Long term follow-up of a large series at a single institution A matched-cohort analysis

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Abstract

Purpose Oncoplastic surgery is a well-established discipline that combines conserving treatment for breast cancer with immediate plastic reconstruction. Although widely practiced, the oncologic outcomes of this combined approach are reported only in small series. The aim of the present paper is to assess the safety of oncoplastic surgery for invasive primary breast cancer. Methods We compared 454 consecutive patients who underwent an oncoplastic approach between 2000 and 2008 for primary invasive breast tumors (study group) with twice the number of patients who received conservation alone in the same interval time (control group). Disease free survival and overall survival were estimated using the Kaplan-Meier method. The log-rank test was used to assess differences between groups. Results The median follow-up was 7.2 years. The overall survival is similar within the two groups, being 91.4% and 91.3% at 10-yr in the study group and in the control group respectively. The disease free survival is slightly lower in the oncoplastic group (69 vs.73.1% at 10-yr). The difference is not statistically significant. Discussion. We have compared a large series of primary breast cancer patients that have undergone oncoplastic surgery (454) with a control group (908) and they were followed for a prolonged period of time. It provides the best available evidence to suggest that oncoplastic surgery is a safe and reliable treatment option for the managing of invasive breast cancer.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Segmental Mastectomy
Cohort Studies
Breast Neoplasms
Control Groups
Disease-Free Survival
Survival
Safety
Therapeutics

Keywords

  • Conservative treatment
  • Invasive breast cancer
  • Local recurrence
  • Oncoplastic surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

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title = "Oncological results of oncoplastic breast-conserving surgery: Long term follow-up of a large series at a single institution A matched-cohort analysis",
abstract = "Purpose Oncoplastic surgery is a well-established discipline that combines conserving treatment for breast cancer with immediate plastic reconstruction. Although widely practiced, the oncologic outcomes of this combined approach are reported only in small series. The aim of the present paper is to assess the safety of oncoplastic surgery for invasive primary breast cancer. Methods We compared 454 consecutive patients who underwent an oncoplastic approach between 2000 and 2008 for primary invasive breast tumors (study group) with twice the number of patients who received conservation alone in the same interval time (control group). Disease free survival and overall survival were estimated using the Kaplan-Meier method. The log-rank test was used to assess differences between groups. Results The median follow-up was 7.2 years. The overall survival is similar within the two groups, being 91.4{\%} and 91.3{\%} at 10-yr in the study group and in the control group respectively. The disease free survival is slightly lower in the oncoplastic group (69 vs.73.1{\%} at 10-yr). The difference is not statistically significant. Discussion. We have compared a large series of primary breast cancer patients that have undergone oncoplastic surgery (454) with a control group (908) and they were followed for a prolonged period of time. It provides the best available evidence to suggest that oncoplastic surgery is a safe and reliable treatment option for the managing of invasive breast cancer.",
keywords = "Conservative treatment, Invasive breast cancer, Local recurrence, Oncoplastic surgery",
author = "{De Lorenzi}, F. and Gabriel Hubner and N. Rotmensz and V. Bagnardi and P. Loschi and P. Maisonneuve and Marco Venturino and R. Orecchia and V. Galimberti and P. Veronesi and M. Rietjens",
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T1 - Oncological results of oncoplastic breast-conserving surgery

T2 - Long term follow-up of a large series at a single institution A matched-cohort analysis

AU - De Lorenzi, F.

AU - Hubner, Gabriel

AU - Rotmensz, N.

AU - Bagnardi, V.

AU - Loschi, P.

AU - Maisonneuve, P.

AU - Venturino, Marco

AU - Orecchia, R.

AU - Galimberti, V.

AU - Veronesi, P.

AU - Rietjens, M.

PY - 2016/1/1

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N2 - Purpose Oncoplastic surgery is a well-established discipline that combines conserving treatment for breast cancer with immediate plastic reconstruction. Although widely practiced, the oncologic outcomes of this combined approach are reported only in small series. The aim of the present paper is to assess the safety of oncoplastic surgery for invasive primary breast cancer. Methods We compared 454 consecutive patients who underwent an oncoplastic approach between 2000 and 2008 for primary invasive breast tumors (study group) with twice the number of patients who received conservation alone in the same interval time (control group). Disease free survival and overall survival were estimated using the Kaplan-Meier method. The log-rank test was used to assess differences between groups. Results The median follow-up was 7.2 years. The overall survival is similar within the two groups, being 91.4% and 91.3% at 10-yr in the study group and in the control group respectively. The disease free survival is slightly lower in the oncoplastic group (69 vs.73.1% at 10-yr). The difference is not statistically significant. Discussion. We have compared a large series of primary breast cancer patients that have undergone oncoplastic surgery (454) with a control group (908) and they were followed for a prolonged period of time. It provides the best available evidence to suggest that oncoplastic surgery is a safe and reliable treatment option for the managing of invasive breast cancer.

AB - Purpose Oncoplastic surgery is a well-established discipline that combines conserving treatment for breast cancer with immediate plastic reconstruction. Although widely practiced, the oncologic outcomes of this combined approach are reported only in small series. The aim of the present paper is to assess the safety of oncoplastic surgery for invasive primary breast cancer. Methods We compared 454 consecutive patients who underwent an oncoplastic approach between 2000 and 2008 for primary invasive breast tumors (study group) with twice the number of patients who received conservation alone in the same interval time (control group). Disease free survival and overall survival were estimated using the Kaplan-Meier method. The log-rank test was used to assess differences between groups. Results The median follow-up was 7.2 years. The overall survival is similar within the two groups, being 91.4% and 91.3% at 10-yr in the study group and in the control group respectively. The disease free survival is slightly lower in the oncoplastic group (69 vs.73.1% at 10-yr). The difference is not statistically significant. Discussion. We have compared a large series of primary breast cancer patients that have undergone oncoplastic surgery (454) with a control group (908) and they were followed for a prolonged period of time. It provides the best available evidence to suggest that oncoplastic surgery is a safe and reliable treatment option for the managing of invasive breast cancer.

KW - Conservative treatment

KW - Invasive breast cancer

KW - Local recurrence

KW - Oncoplastic surgery

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