Oncology of companion animals as a model for humans. An overview of tumor histotypes

A. Porrello, P. Cardelli, E. P. Spugnini

Research output: Contribution to journalArticlepeer-review

Abstract

The need for more appropriate animal models in cancer research has led, over the past 20 years, to consider pets with spontaneously occurring neoplasms as a valuable and still under used resource. The role of companion animals in the struggle to eradicate cancer can be multiple: they may act as environmental sentinels, help in gain-ing insights on tumor biology and finally may be enrolled in therapeutic trials which might act as a bridge to the clinic applications. This paper will focus on the most valuable spontaneous neoplasms in companion animals and will analyze the potentials of each histotype as a model for basic research and for new therapeutic strategies. It is conceivable that in the next years comparative oncology will play a paramount role in translational medicine allowing a rapid flow of data from laboratories to clinical application in humans.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalJournal of Experimental and Clinical Cancer Research
Volume25
Issue number1
Publication statusPublished - Mar 2006

Keywords

  • Cat
  • Dog
  • Model
  • Neoplasia
  • Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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