Oncosuppressor genes: mechanisms of inactivation for the retinoblastoma gene and p53.

L. Clerico, T. Mancuso, D. Noonan, A. Albini

Research output: Contribution to journalArticle

Abstract

Mutations that affect oncosuppressor genes contribute to transformed phenotype. The recessive characteristics of these genes require mutations on both alleles. For this reason alterations of the oncosuppressor genes can be transmitted with the germ line. In this review we focus on mechanisms of inactivation of the retinoblastoma gene and p53. The products of these genes are nuclear phosphoproteins involved in controlling cellular proliferation. Inactivated Rb genes have been found in several tumor types. The phosphorylation of the Rb gene product, p105Rb, is regulated by cyclin-dependent kinases in accordance with the cell cycle. Hypophosphorylated wild-type p105Rb is tightly bound to the nuclear matrix and seems to be critical in inhibition of cellular proliferation. Hyperphosphorylation is a physiological mechanism of inactivation of p105Rb. The p53 gene product is a transcriptional factor that blocks the progression of cell division. Mutations in the p53 gene are frequently found in many human cancers and are localized in the highly conserved region of the gene. The protein product of the mutated gene looses its function as a negative regulator of cellular proliferation. The wild-type protein can also be inactivated by forming stable complex with a mutated p53 protein or with the SV large T antigen.

Original languageEnglish
Pages (from-to)725-734
Number of pages10
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume69
Issue number12
Publication statusPublished - Dec 1993

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Retinoblastoma Genes
Gene Silencing
p53 Genes
Cell Proliferation
Mutation
Genes
Recessive Genes
Nuclear Matrix
Retinoblastoma Protein
Proteins
Cyclin-Dependent Kinases
Phosphoproteins
Viral Tumor Antigens
Germ Cells
Cell Division
Neoplasms
Cell Cycle
Alleles
Phosphorylation
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

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Oncosuppressor genes : mechanisms of inactivation for the retinoblastoma gene and p53. / Clerico, L.; Mancuso, T.; Noonan, D.; Albini, A.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 69, No. 12, 12.1993, p. 725-734.

Research output: Contribution to journalArticle

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