One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Andrea Fuso, Sigfrido Scarpa

Research output: Contribution to journalArticlepeer-review

Abstract

The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.

Original languageEnglish
Pages (from-to)1192-1195
Number of pages4
JournalNeurobiology of Aging
Volume32
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • B vitamins
  • DNA methylation
  • Homocysteine
  • Late onset AD
  • One-carbon metabolism
  • Protein methylation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

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