One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Andrea Fuso; Sigfrido Scarpa

doi:10.1016/j.neurobiolaging.2011.01.012

One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Andrea Fuso, Sigfrido Scarpa

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.

Original language	English
Pages (from-to)	1192-1195
Number of pages	4
Journal	Neurobiology of Aging
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.01.012
Publication status	Published - Jul 2011

Keywords

B vitamins
DNA methylation
Homocysteine
Late onset AD
One-carbon metabolism
Protein methylation

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2011.01.012

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title = "One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?",

abstract = "The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.",

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KW - Homocysteine

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KW - One-carbon metabolism

KW - Protein methylation

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One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Abstract

Keywords

ASJC Scopus subject areas

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