One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Andrea Fuso; Sigfrido Scarpa

doi:10.1016/j.neurobiolaging.2011.01.012

One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?

Andrea Fuso, Sigfrido Scarpa

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.

Original language	English
Pages (from-to)	1192-1195
Number of pages	4
Journal	Neurobiology of Aging
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.01.012
Publication status	Published - Jul 2011

Keywords

B vitamins
DNA methylation
Homocysteine
Late onset AD
One-carbon metabolism
Protein methylation

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

Access to Document

10.1016/j.neurobiolaging.2011.01.012

Fingerprint Dive into the research topics of 'One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?'. Together they form a unique fingerprint.

Cite this

@article{a4faf20eac9544f9940cbcd6de21ff7c,

title = "One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?",

abstract = "The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.",

keywords = "B vitamins, DNA methylation, Homocysteine, Late onset AD, One-carbon metabolism, Protein methylation",

author = "Andrea Fuso and Sigfrido Scarpa",

year = "2011",

month = jul,

doi = "10.1016/j.neurobiolaging.2011.01.012",

language = "English",

volume = "32",

pages = "1192--1195",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - One-carbon metabolism and Alzheimer's disease

T2 - Is it all a methylation matter?

AU - Fuso, Andrea

AU - Scarpa, Sigfrido

PY - 2011/7

Y1 - 2011/7

N2 - The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.

AB - The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.

KW - B vitamins

KW - DNA methylation

KW - Homocysteine

KW - Late onset AD

KW - One-carbon metabolism

KW - Protein methylation

UR - http://www.scopus.com/inward/record.url?scp=79958766232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958766232&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2011.01.012

DO - 10.1016/j.neurobiolaging.2011.01.012

M3 - Article

C2 - 21524430

AN - SCOPUS:79958766232

VL - 32

SP - 1192

EP - 1195

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 7

ER -