Abstract
The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 1192-1195 |
| Number of pages | 4 |
| Journal | Neurobiology of Aging |
| Volume | 32 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2011 |
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Keywords
- B vitamins
- DNA methylation
- Homocysteine
- Late onset AD
- One-carbon metabolism
- Protein methylation
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Ageing
- Developmental Biology
- Geriatrics and Gerontology
Cite this
One-carbon metabolism and Alzheimer's disease : Is it all a methylation matter? / Fuso, Andrea; Scarpa, Sigfrido.
In: Neurobiology of Aging, Vol. 32, No. 7, 07.2011, p. 1192-1195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - One-carbon metabolism and Alzheimer's disease
T2 - Is it all a methylation matter?
AU - Fuso, Andrea
AU - Scarpa, Sigfrido
PY - 2011/7
Y1 - 2011/7
N2 - The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.
AB - The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the coinvolvement of this metabolism in amylod and tau pathways.
KW - B vitamins
KW - DNA methylation
KW - Homocysteine
KW - Late onset AD
KW - One-carbon metabolism
KW - Protein methylation
UR - http://www.scopus.com/inward/record.url?scp=79958766232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958766232&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2011.01.012
DO - 10.1016/j.neurobiolaging.2011.01.012
M3 - Article
C2 - 21524430
AN - SCOPUS:79958766232
VL - 32
SP - 1192
EP - 1195
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 7
ER -