One or two operator technique and quality performance of colonoscopy: A randomised controlled trial

Silvia Paggi, Emanuele Rondonotti, Arnaldo Amato, Alessandra Baccarin, Giancarlo Spinzi, Franco Radaelli

Research output: Contribution to journalArticlepeer-review


Background: The two-operator technique for colonoscopy, with the endoscopy assistant actively advancing and withdrawing the scope, is still commonly practiced in Europe. As uncontrolled data has suggested that the one-operator technique is associated with a higher adenoma detection rate, we tested the hypothesis that the two-operator-technique can achieve comparable performances in terms of adenoma detection. Methods: Non-inferiority trial in which consecutive adult outpatients were randomised to undergo colonoscopy by one (one-operator) or by four endoscopists. Each performed half the procedures by one-operator and half by two-operator technique independently of routine clinical practice. Main outcome measure was adenoma detection rate. Results: 352 subjects (49% males, mean age 60 ± 12.1 years) were randomised to one (n= 176) or to two-operator technique (n= 176) colonoscopy. No significant differences were found in adenoma detection (33% vs. 30.7%, p= 0.65), or cecal intubation rate, procedure times, and patient tolerability. No differences were found in the subgroup analysis according to routinely adopted colonoscopy technique. Conclusions: This study does not confirm a higher adenoma detection rate for one-operator technique colonoscopy. Changing current practice to improve adenoma detection rate for endoscopists routinely using two-operator technique is not warranted.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalDigestive and Liver Disease
Issue number7
Publication statusPublished - 2014


  • Adenoma detection rate
  • Colonoscopy technique
  • One operator
  • Two operators

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)


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