One-stage exchange with antibacterial hydrogel coated implants provides similar results to two-stage revision, without the coating, for the treatment of peri-prosthetic infection

Nicola Capuano, Nicola Logoluso, Enrico Gallazzi, Lorenzo Drago, Carlo Luca Romanò

Research output: Contribution to journalArticle

Abstract

Purpose: Aim of this study was to verify the hypothesis that a one-stage exchange procedure, performed with an antibiotic-loaded, fast-resorbable hydrogel coating, provides similar infection recurrence rate than a two-stage procedure without the coating, in patients affected by peri-prosthetic joint infection (PJI). Methods: In this two-center case–control, study, 22 patients, treated with a one-stage procedure, using implants coated with an antibiotic-loaded hydrogel [defensive antibacterial coating (DAC)], were compared with 22 retrospective matched controls, treated with a two-stage revision procedure, without the coating. Results: At a mean follow-up of 29.3 ± 5.0 months, two patients (9.1%) in the DAC group showed an infection recurrence, compared to three patients (13.6%) in the two-stage group. Clinical scores were similar between groups, while average hospital stay and antibiotic treatment duration were significantly reduced after one-stage, compared to two-stage (18.9 ± 2.9 versus 35.8 ± 3.4 and 23.5 ± 3.3 versus 53.7 ± 5.6 days, respectively). Conclusions: Although in a relatively limited series of patients, our data shows similar infection recurrence rate after one-stage exchange with DAC-coated implants, compared to two-stage revision without coating, with reduced overall hospitalization time and antibiotic treatment duration. These findings warrant further studies in the possible applications of antibacterial coating technologies to treat implant-related infections. Level of evidence: III.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Coating
  • DAC
  • Infection
  • One-stage revision
  • PJI
  • Two-stage revision

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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