One-stage Penile Urethroplasty Using Oral Mucosal Graft and Glue

Guido Barbagli, Graziella Pellegrini, F. Corradini, Francesco Montorsi, Salvatore Sansalone, Denis Butnaru, Massimo Lazzeri

Research output: Contribution to journalArticle

Abstract

Background: Repair of penile urethral strictures is a challenging problem for which different techniques have been suggested. Objective: To describe a new surgical technique for one-stage penile urethroplasty using an oral graft and glue, and to assess its safety and efficacy. Design, setting, and participants: A retrospective review of medical records for patients who underwent one-stage penile urethroplasty using oral mucosa and glue from February 2013 to October 2014 was performed. Surgical procedure: The penile urethra was opened and the urethral plate was incised to create a wide window within which the oral graft was pasted with glue. The urethra was sutured over the catheter. Outcome measurements and statistical analysis: Clinical data were collected in a database. Intraoperative and postoperative complications and outcomes were assessed. A descriptive statistical analysis was performed. Results and limitations: Fourteen patients were included in the study. Median operative time was 60. min. The median postoperative stay was 3 d. Three intraoperative and one postoperative complication occurred. In all patients, voiding cystourethrography 2 wk after surgery failed to show urethral fistula or sacculation. No patients complained of penile chordee or sexual dysfunction after surgery. Median follow-up was 16 mo. Among the 14 patients, 12 (85.7%) procedures were successful and two (14.3%) were failures. Study limitations include the small sample size and short follow-up. Conclusions: An in vitro study and a one-stage reconstruction of penile urethral strictures with an oral mucosa graft and glue showed that the procedure is safe and efficient, but further studies including larger series of patients and longer follow-up are required. Patient summary: We report on the repair of penile urethral stricture using one-stage urethroplasty with oral mucosa and glue. This new technique was safe and effective, with limited complications and satisfactory outcomes. We plan to increase the use of this technique in the future. The combined use of oral mucosa and glue for one-stage penile urethroplasty is safe and efficient and, in our experience, considerably increases the success rate for this type of urethroplasty.

Original languageEnglish
JournalEuropean Urology
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • Glue
  • One-stage urethroplasty
  • Oral mucosal graft
  • Penile stricture

ASJC Scopus subject areas

  • Urology

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